Abstract
To evaluate the association between worldwide ALS incidence rates and age, using a dose–response meta-analysis. We reviewed Medline and Embase up to July 2016 and included all population-based studies of newly-diagnosed cases, using multiple sources for case ascertainment. A dose–response meta-analysis was performed. A meta-regression investigated potential sources of heterogeneity. Of 3254 articles identified in the literature, we included 41 incidence studies covering 42 geographical areas. Overall, the fit between observed and predicted age-specific rates was very good. The expected variation of ALS incidence with age was characterized, in each study, by a progressive increase in the incidence from the 40s leading to a peak in the 60s or 70s, followed by a sharp decrease. Cochran’s Q test suggested a significant heterogeneity between studies. Overall, estimated patterns of ALS age-specific incidence (at which the peak was reached) were similar among subcontinents of Europe and North America: peak of ALS incidence ranged in these areas between 6.98 and 8.17/100,000 PYFU, which referred to age in the range 71.6–77.4 years. The relationship between age and ALS incidence appeared different for Eastern Asia which was characterized by a peak of ALS incidence at 2.20/100,000 PYFU around 75 years of age. This study confirms the consistency of the age-specific ALS incidence pattern within different subcontinents. Age-specific incidence appears lower in Eastern Asia as compared to Europe and North America.
| Original language | English |
|---|---|
| Pages (from-to) | 621-634 |
| Number of pages | 14 |
| Journal | European Journal of Epidemiology |
| Volume | 33 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2018 |
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Keywords
- Age-specific
- Amyotrophic lateral sclerosis
- Epidemiology
- Ethnic groups
- Incidence
ASJC Scopus subject areas
- Epidemiology
Cite this
Age-specific ALS incidence : a dose–response meta-analysis. / Marin, Benoît; Fontana, Andrea; Arcuti, Simona; Copetti, Massimilano; Boumédiene, Farid; Couratier, Philippe; Beghi, Ettore; Preux, Pierre Marie; Logroscino, Giancarlo.
In: European Journal of Epidemiology, Vol. 33, No. 7, 01.07.2018, p. 621-634.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-specific ALS incidence
T2 - a dose–response meta-analysis
AU - Marin, Benoît
AU - Fontana, Andrea
AU - Arcuti, Simona
AU - Copetti, Massimilano
AU - Boumédiene, Farid
AU - Couratier, Philippe
AU - Beghi, Ettore
AU - Preux, Pierre Marie
AU - Logroscino, Giancarlo
PY - 2018/7/1
Y1 - 2018/7/1
N2 - To evaluate the association between worldwide ALS incidence rates and age, using a dose–response meta-analysis. We reviewed Medline and Embase up to July 2016 and included all population-based studies of newly-diagnosed cases, using multiple sources for case ascertainment. A dose–response meta-analysis was performed. A meta-regression investigated potential sources of heterogeneity. Of 3254 articles identified in the literature, we included 41 incidence studies covering 42 geographical areas. Overall, the fit between observed and predicted age-specific rates was very good. The expected variation of ALS incidence with age was characterized, in each study, by a progressive increase in the incidence from the 40s leading to a peak in the 60s or 70s, followed by a sharp decrease. Cochran’s Q test suggested a significant heterogeneity between studies. Overall, estimated patterns of ALS age-specific incidence (at which the peak was reached) were similar among subcontinents of Europe and North America: peak of ALS incidence ranged in these areas between 6.98 and 8.17/100,000 PYFU, which referred to age in the range 71.6–77.4 years. The relationship between age and ALS incidence appeared different for Eastern Asia which was characterized by a peak of ALS incidence at 2.20/100,000 PYFU around 75 years of age. This study confirms the consistency of the age-specific ALS incidence pattern within different subcontinents. Age-specific incidence appears lower in Eastern Asia as compared to Europe and North America.
AB - To evaluate the association between worldwide ALS incidence rates and age, using a dose–response meta-analysis. We reviewed Medline and Embase up to July 2016 and included all population-based studies of newly-diagnosed cases, using multiple sources for case ascertainment. A dose–response meta-analysis was performed. A meta-regression investigated potential sources of heterogeneity. Of 3254 articles identified in the literature, we included 41 incidence studies covering 42 geographical areas. Overall, the fit between observed and predicted age-specific rates was very good. The expected variation of ALS incidence with age was characterized, in each study, by a progressive increase in the incidence from the 40s leading to a peak in the 60s or 70s, followed by a sharp decrease. Cochran’s Q test suggested a significant heterogeneity between studies. Overall, estimated patterns of ALS age-specific incidence (at which the peak was reached) were similar among subcontinents of Europe and North America: peak of ALS incidence ranged in these areas between 6.98 and 8.17/100,000 PYFU, which referred to age in the range 71.6–77.4 years. The relationship between age and ALS incidence appeared different for Eastern Asia which was characterized by a peak of ALS incidence at 2.20/100,000 PYFU around 75 years of age. This study confirms the consistency of the age-specific ALS incidence pattern within different subcontinents. Age-specific incidence appears lower in Eastern Asia as compared to Europe and North America.
KW - Age-specific
KW - Amyotrophic lateral sclerosis
KW - Epidemiology
KW - Ethnic groups
KW - Incidence
UR - http://www.scopus.com/inward/record.url?scp=85045835234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045835234&partnerID=8YFLogxK
U2 - 10.1007/s10654-018-0392-x
DO - 10.1007/s10654-018-0392-x
M3 - Article
AN - SCOPUS:85045835234
VL - 33
SP - 621
EP - 634
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
IS - 7
ER -