Age-specific ALS incidence: a dose–response meta-analysis

Benoît Marin, Andrea Fontana, Simona Arcuti, Massimilano Copetti, Farid Boumédiene, Philippe Couratier, Ettore Beghi, Pierre Marie Preux, Giancarlo Logroscino

Research output: Contribution to journalArticle

Abstract

To evaluate the association between worldwide ALS incidence rates and age, using a dose–response meta-analysis. We reviewed Medline and Embase up to July 2016 and included all population-based studies of newly-diagnosed cases, using multiple sources for case ascertainment. A dose–response meta-analysis was performed. A meta-regression investigated potential sources of heterogeneity. Of 3254 articles identified in the literature, we included 41 incidence studies covering 42 geographical areas. Overall, the fit between observed and predicted age-specific rates was very good. The expected variation of ALS incidence with age was characterized, in each study, by a progressive increase in the incidence from the 40s leading to a peak in the 60s or 70s, followed by a sharp decrease. Cochran’s Q test suggested a significant heterogeneity between studies. Overall, estimated patterns of ALS age-specific incidence (at which the peak was reached) were similar among subcontinents of Europe and North America: peak of ALS incidence ranged in these areas between 6.98 and 8.17/100,000 PYFU, which referred to age in the range 71.6–77.4 years. The relationship between age and ALS incidence appeared different for Eastern Asia which was characterized by a peak of ALS incidence at 2.20/100,000 PYFU around 75 years of age. This study confirms the consistency of the age-specific ALS incidence pattern within different subcontinents. Age-specific incidence appears lower in Eastern Asia as compared to Europe and North America.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
JournalEuropean Journal of Epidemiology
Volume33
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

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Meta-Analysis
Incidence
Far East
North America
Cohort Studies
Population

Keywords

  • Age-specific
  • Amyotrophic lateral sclerosis
  • Epidemiology
  • Ethnic groups
  • Incidence

ASJC Scopus subject areas

  • Epidemiology

Cite this

Marin, B., Fontana, A., Arcuti, S., Copetti, M., Boumédiene, F., Couratier, P., ... Logroscino, G. (2018). Age-specific ALS incidence: a dose–response meta-analysis. European Journal of Epidemiology, 33(7), 621-634. https://doi.org/10.1007/s10654-018-0392-x

Age-specific ALS incidence : a dose–response meta-analysis. / Marin, Benoît; Fontana, Andrea; Arcuti, Simona; Copetti, Massimilano; Boumédiene, Farid; Couratier, Philippe; Beghi, Ettore; Preux, Pierre Marie; Logroscino, Giancarlo.

In: European Journal of Epidemiology, Vol. 33, No. 7, 01.07.2018, p. 621-634.

Research output: Contribution to journalArticle

Marin, B, Fontana, A, Arcuti, S, Copetti, M, Boumédiene, F, Couratier, P, Beghi, E, Preux, PM & Logroscino, G 2018, 'Age-specific ALS incidence: a dose–response meta-analysis', European Journal of Epidemiology, vol. 33, no. 7, pp. 621-634. https://doi.org/10.1007/s10654-018-0392-x
Marin, Benoît ; Fontana, Andrea ; Arcuti, Simona ; Copetti, Massimilano ; Boumédiene, Farid ; Couratier, Philippe ; Beghi, Ettore ; Preux, Pierre Marie ; Logroscino, Giancarlo. / Age-specific ALS incidence : a dose–response meta-analysis. In: European Journal of Epidemiology. 2018 ; Vol. 33, No. 7. pp. 621-634.
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