Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients

Fabiola Olivieri, Roberta Galeazzi, Davide Giavarina, Roberto Testa, Angela Marie Abbatecola, Artan Çeka, Paola Tamburrini, Franco Busco, Raffaella Lazzarini, Daniela Monti, Claudio Franceschi, Antonio Domenico Procopio, Roberto Antonicelli

Research output: Contribution to journalArticle

Abstract

High sensitive cardiac Troponin T (hs-cTnT) represents an important tool in acute myocardial infarction (AMI) diagnosis. Even though the hs-cTnT evaluation is relevant for AMI diagnosis in elderly patients characterized by clinical and instrumental atypical presentation, the overall reliability in elderly patients is unknown. We aimed at: (1) defining the hs-cTnT 99th percentile value in an aged healthy reference population and (2) testing hs-cTnT diagnostic accuracy in elderly patients with a suspected AMI.294 healthy subjects (50-105 years old) and 299 elderly patients (75-96 years old) with suspected AMI at presentation, were enrolled. Conventional cTnT, hs-cTnT, NT-proBNP and creatinine levels were determined in all participants.Our main results are: (1) a significant hs-cTnT age-related increase was observed in an healthy reference population ranging 50-105 years old; (2) hs-cTnT levels showed an age-related multimodal distribution in the healthy reference population: 16. ng/L corresponds to the 99th percentile in subjects ranging 50-75 years old, whereas 70.6. ng/L corresponds to the 99th percentile in subjects ≥75 years old; (3) 86.8. ng/L resulted the hs-cTnT cut-off value with the highest efficiency in AMI diagnosis of geriatric patients.Our data suggest that the hs-cTnT cut-off value must be age-tailored to improve the AMI diagnostic accuracy.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalMechanisms of Ageing and Development
Volume133
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • Acute myocardial infarction
  • Cardiac Troponin T
  • Centenarians
  • Congestive heart failure

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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