Abstract
High sensitive cardiac Troponin T (hs-cTnT) represents an important tool in acute myocardial infarction (AMI) diagnosis. Even though the hs-cTnT evaluation is relevant for AMI diagnosis in elderly patients characterized by clinical and instrumental atypical presentation, the overall reliability in elderly patients is unknown. We aimed at: (1) defining the hs-cTnT 99th percentile value in an aged healthy reference population and (2) testing hs-cTnT diagnostic accuracy in elderly patients with a suspected AMI.294 healthy subjects (50-105 years old) and 299 elderly patients (75-96 years old) with suspected AMI at presentation, were enrolled. Conventional cTnT, hs-cTnT, NT-proBNP and creatinine levels were determined in all participants.Our main results are: (1) a significant hs-cTnT age-related increase was observed in an healthy reference population ranging 50-105 years old; (2) hs-cTnT levels showed an age-related multimodal distribution in the healthy reference population: 16. ng/L corresponds to the 99th percentile in subjects ranging 50-75 years old, whereas 70.6. ng/L corresponds to the 99th percentile in subjects ≥75 years old; (3) 86.8. ng/L resulted the hs-cTnT cut-off value with the highest efficiency in AMI diagnosis of geriatric patients.Our data suggest that the hs-cTnT cut-off value must be age-tailored to improve the AMI diagnostic accuracy.
| Original language | English |
|---|---|
| Pages (from-to) | 300-305 |
| Number of pages | 6 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 133 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2012 |
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Keywords
- Acute myocardial infarction
- Cardiac Troponin T
- Centenarians
- Congestive heart failure
ASJC Scopus subject areas
- Ageing
- Developmental Biology
Cite this
Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients. / Olivieri, Fabiola; Galeazzi, Roberta; Giavarina, Davide; Testa, Roberto; Abbatecola, Angela Marie; Çeka, Artan; Tamburrini, Paola; Busco, Franco; Lazzarini, Raffaella; Monti, Daniela; Franceschi, Claudio; Procopio, Antonio Domenico; Antonicelli, Roberto.
In: Mechanisms of Ageing and Development, Vol. 133, No. 5, 05.2012, p. 300-305.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients
AU - Olivieri, Fabiola
AU - Galeazzi, Roberta
AU - Giavarina, Davide
AU - Testa, Roberto
AU - Abbatecola, Angela Marie
AU - Çeka, Artan
AU - Tamburrini, Paola
AU - Busco, Franco
AU - Lazzarini, Raffaella
AU - Monti, Daniela
AU - Franceschi, Claudio
AU - Procopio, Antonio Domenico
AU - Antonicelli, Roberto
PY - 2012/5
Y1 - 2012/5
N2 - High sensitive cardiac Troponin T (hs-cTnT) represents an important tool in acute myocardial infarction (AMI) diagnosis. Even though the hs-cTnT evaluation is relevant for AMI diagnosis in elderly patients characterized by clinical and instrumental atypical presentation, the overall reliability in elderly patients is unknown. We aimed at: (1) defining the hs-cTnT 99th percentile value in an aged healthy reference population and (2) testing hs-cTnT diagnostic accuracy in elderly patients with a suspected AMI.294 healthy subjects (50-105 years old) and 299 elderly patients (75-96 years old) with suspected AMI at presentation, were enrolled. Conventional cTnT, hs-cTnT, NT-proBNP and creatinine levels were determined in all participants.Our main results are: (1) a significant hs-cTnT age-related increase was observed in an healthy reference population ranging 50-105 years old; (2) hs-cTnT levels showed an age-related multimodal distribution in the healthy reference population: 16. ng/L corresponds to the 99th percentile in subjects ranging 50-75 years old, whereas 70.6. ng/L corresponds to the 99th percentile in subjects ≥75 years old; (3) 86.8. ng/L resulted the hs-cTnT cut-off value with the highest efficiency in AMI diagnosis of geriatric patients.Our data suggest that the hs-cTnT cut-off value must be age-tailored to improve the AMI diagnostic accuracy.
AB - High sensitive cardiac Troponin T (hs-cTnT) represents an important tool in acute myocardial infarction (AMI) diagnosis. Even though the hs-cTnT evaluation is relevant for AMI diagnosis in elderly patients characterized by clinical and instrumental atypical presentation, the overall reliability in elderly patients is unknown. We aimed at: (1) defining the hs-cTnT 99th percentile value in an aged healthy reference population and (2) testing hs-cTnT diagnostic accuracy in elderly patients with a suspected AMI.294 healthy subjects (50-105 years old) and 299 elderly patients (75-96 years old) with suspected AMI at presentation, were enrolled. Conventional cTnT, hs-cTnT, NT-proBNP and creatinine levels were determined in all participants.Our main results are: (1) a significant hs-cTnT age-related increase was observed in an healthy reference population ranging 50-105 years old; (2) hs-cTnT levels showed an age-related multimodal distribution in the healthy reference population: 16. ng/L corresponds to the 99th percentile in subjects ranging 50-75 years old, whereas 70.6. ng/L corresponds to the 99th percentile in subjects ≥75 years old; (3) 86.8. ng/L resulted the hs-cTnT cut-off value with the highest efficiency in AMI diagnosis of geriatric patients.Our data suggest that the hs-cTnT cut-off value must be age-tailored to improve the AMI diagnostic accuracy.
KW - Acute myocardial infarction
KW - Cardiac Troponin T
KW - Centenarians
KW - Congestive heart failure
UR - http://www.scopus.com/inward/record.url?scp=84861233257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861233257&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2012.03.005
DO - 10.1016/j.mad.2012.03.005
M3 - Article
C2 - 22446505
AN - SCOPUS:84861233257
VL - 133
SP - 300
EP - 305
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 5
ER -