TY - JOUR
T1 - Ageing affects cytosolic Ca2+ binding proteins and synaptic markers in the retina but not in cerebral cortex neurons of the rat
AU - Papazariri, Panagiota
AU - Podini, Paola
AU - Meldolesi, Jacopo
AU - Yamaguchi, Tomoko
PY - 1995/2/15
Y1 - 1995/2/15
N2 - Two cerebral cortex areas (frontal and occipital) and the retina of rats varying in age from 0.4 to 30 months were investigated for the expression levels and distribution of two cytosolic high affinity Ca2+ binding proteins, calbindin-28 and calretinin, and of two presynaptic protein markers. Of these latter proteins, one is integral (synaptophysin) the other peripheral (synapsin I) to the synaptic vesicle membranes. In the cortex areas, no significant changes of the markers were observed, except for a drop of calretinin from 0.4 to 2 months, probably related to a stage of neuronal development. In the retina, calbindin-28 decreased progressively during ageing (-40% at 30 months) while calretinin remained unchanged. Concomitantly, the two synaptic vesicle proteins dropped, synaptophysin >50% and synapsin I >85%. The role of these changes in sustaining the functional alterations previously described in the retina of aged animals remains to be investigated.
AB - Two cerebral cortex areas (frontal and occipital) and the retina of rats varying in age from 0.4 to 30 months were investigated for the expression levels and distribution of two cytosolic high affinity Ca2+ binding proteins, calbindin-28 and calretinin, and of two presynaptic protein markers. Of these latter proteins, one is integral (synaptophysin) the other peripheral (synapsin I) to the synaptic vesicle membranes. In the cortex areas, no significant changes of the markers were observed, except for a drop of calretinin from 0.4 to 2 months, probably related to a stage of neuronal development. In the retina, calbindin-28 decreased progressively during ageing (-40% at 30 months) while calretinin remained unchanged. Concomitantly, the two synaptic vesicle proteins dropped, synaptophysin >50% and synapsin I >85%. The role of these changes in sustaining the functional alterations previously described in the retina of aged animals remains to be investigated.
KW - Ageing
KW - Brain
KW - Calcium binding protein
KW - Rat
KW - Retina
KW - Synapsin
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U2 - 10.1016/0304-3940(95)11285-5
DO - 10.1016/0304-3940(95)11285-5
M3 - Article
C2 - 7783952
AN - SCOPUS:0028890882
VL - 186
SP - 65
EP - 68
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -