Ageing and gut microbes: Perspectives for health maintenance and longevity

Elena Biagi, Marco Candela, Silvia Turroni, Paolo Garagnani, Claudio Franceschi, Patrizia Brigidi

Research output: Contribution to journalArticle

Abstract

The ageing process affects the human gut microbiota phylogenetic composition and its interaction with the immune system. Age-related gut microbiota modifications are associated with immunosenescence and inflamm-ageing in a sort of self-sustaining loop, which allows the placement of gut microbiota unbalances among both the causes and the effects of the inflamm-ageing process. Even if, up to now, the link between gut microbiota and the ageing process is only partially understood, the gut ecosystem shows the potential to become a promising target for strategies able to contribute to the health status of older people. In this context, the consumption of pro/prebiotics may be useful in both prevention and treatment of age-related pathophysiological conditions, such as recovery and promotion of immune functions, i.e. adjuvant effect for influenza vaccine, and prevention and/or alleviation of common "winter diseases", as well as constipation and Clostridium difficile-associated diarrhoea. Moreover, being involved in different mechanisms which concur in counteracting inflammation, such as down-regulation of inflammation-associated genes and improvement of colonic mucosa conditions, probiotics have the potentiality to be involved in the promotion of longevity.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalPharmacological Research
Volume69
Issue number1
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Ageing
  • Immunosenescence
  • Intestinal microbiota
  • Longevity
  • Probiotics

ASJC Scopus subject areas

  • Pharmacology

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