Ageing of rabbit red cells in vitro: Membrane modifications and their possible role in red cell survival in vivo

C. L. Balduini, F. Sinigaglia, E. Ascari, C. Balduini

Research output: Contribution to journalArticle

Abstract

In vitro incubation induces, in rabbit red cell membranes, significant modifications consisting mainly in a decrease of sialic acid and galactose. In vivo the life span of incubated erythrocytes seems to be correlated to the degree of surface alterations and ATP depletion: larger surface modifications and energy charge reduction induce shorter survival time. It can therefore be postulated that incubation of red cell in vitro can cause an ageing process similar to that occurring physiologically in vivo.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalActa Haematologica
Volume65
Issue number4
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Hematology

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