Aggregation of human platelets stimulates calcium ion movement and release reaction

G. Bertolino, C. L. Balduini

Research output: Contribution to journalArticlepeer-review


We studied the effect of inhibition of platelet aggregation (obtained by omitting sample stirring and by the addition of ASA and GRGDS peptide) on ATP secretion and Ca2+ movements. When collagen was the agonist, platelet aggregation stimulated release reaction and Ca2+ movements in both the presence and absence of extracellular Ca2+. When platelets were stimulated by thrombin, ATP release and Ca2+ movements were largely independent of aggregation. Our data suggest that platelet aggregation stimulates Ca2+ movement, and that this phenomenon of feedback amplification of platelet activation plays an important role in platelet function when collagen is the agonist, while it has little or no role when thrombin is the stimulus.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Cell Biology


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