Aggregation properties of GM3 ganglioside (II3Neu5AcLacCer) in aqueous solutions

Sandro Sonnico, Laura Cantu', Domenico Acquotti, Mario Corti, Guido Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

The aggregative properties of highly pure GM3 ganglioside in aqueous solution have been studied by static and dynamic laser light scattering measurements and fluorescence spectroscopy experiments performed by the use of a GM3 derivative containing the pyrene group at the end of the fatty acid moiety. GM3 ganglioside spontaneously aggregates as unilamellar vesicles, down to a concentration of 1.25 × 10-8 M, showing molecular weight and hydrodynamic radius ranging from 15,000 to 30,000 kDa and from 350 to 470 Å, respectively. GM3 vesicles are stable with dilution and can be stored at room temperature for some weeks without appreciable change.

Original languageEnglish
Pages (from-to)231-241
Number of pages11
JournalChemistry and Physics of Lipids
Volume52
Issue number3-4
DOIs
Publication statusPublished - 1990

Keywords

  • ganglioside aggregates
  • ganglioside derivatives
  • gangliosides
  • light scattering
  • vesicles

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

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