Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

Sandro Sonnino; Laura Cantu'; Mario Corti; Domenico Acquotti; Gunther Kirschner; Guido Tettamanti

doi:10.1016/0009-3084(90)90087-8

Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

Sandro Sonnino, Laura Cantu', Mario Corti, Domenico Acquotti, Gunther Kirschner, Guido Tettamanti

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 Å and 102 kDa, respectively, down to a concentration of 2.0 × 10^-5 M.

Original language	English
Pages (from-to)	49-57
Number of pages	9
Journal	Chemistry and Physics of Lipids
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/0009-3084(90)90087-8
Publication status	Published - 1990

Keywords

c.m.c.
ganglioside aggregates
ganglioside derivatives
gangliosides
light scattering
micelles
surface tension

ASJC Scopus subject areas

Biochemistry
Biophysics

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10.1016/0009-3084(90)90087-8

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title = "Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety",

abstract = "The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 {\AA} and 102 kDa, respectively, down to a concentration of 2.0 × 10-5 M.",

keywords = "c.m.c., ganglioside aggregates, ganglioside derivatives, gangliosides, light scattering, micelles, surface tension",

author = "Sandro Sonnino and Laura Cantu' and Mario Corti and Domenico Acquotti and Gunther Kirschner and Guido Tettamanti",

year = "1990",

doi = "10.1016/0009-3084(90)90087-8",

language = "English",

volume = "56",

pages = "49--57",

journal = "Chemistry and Physics of Lipids",

issn = "0009-3084",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

AU - Sonnino, Sandro

AU - Cantu', Laura

AU - Corti, Mario

AU - Acquotti, Domenico

AU - Kirschner, Gunther

AU - Tettamanti, Guido

PY - 1990

Y1 - 1990

N2 - The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 Å and 102 kDa, respectively, down to a concentration of 2.0 × 10-5 M.

AB - The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 Å and 102 kDa, respectively, down to a concentration of 2.0 × 10-5 M.

KW - c.m.c.

KW - ganglioside aggregates

KW - ganglioside derivatives

KW - gangliosides

KW - light scattering

KW - micelles

KW - surface tension

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DO - 10.1016/0009-3084(90)90087-8

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VL - 56

SP - 49

EP - 57

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

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