Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

Sandro Sonnino, Laura Cantu', Mario Corti, Domenico Acquotti, Gunther Kirschner, Guido Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 Å and 102 kDa, respectively, down to a concentration of 2.0 × 10-5 M.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalChemistry and Physics of Lipids
Volume56
Issue number1
DOIs
Publication statusPublished - 1990

Keywords

  • c.m.c.
  • ganglioside aggregates
  • ganglioside derivatives
  • gangliosides
  • light scattering
  • micelles
  • surface tension

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

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