Abstract
Original language | English |
---|---|
Journal | Nutrition |
Volume | 74 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- chronic plaque psoriasis
- ketogenic diet
- Mediterranean diet
- PASI
- Weight loss
- alanine aminotransferase
- aspartate aminotransferase
- creatine kinase
- lactate dehydrogenase
- milk protein
- sodium
- urate
- adult
- alanine aminotransferase blood level
- Article
- aspartate aminotransferase blood level
- asthenia
- bloating
- clinical article
- constipation
- creatine kinase blood level
- Dermatology Life Quality Index
- dietary compliance
- disease severity
- dizziness
- female
- headache
- heart palpitation
- human
- hunger
- lactate dehydrogenase blood level
- low calorie diet
- male
- muscle cramp
- nausea
- obesity
- open study
- priority journal
- proof of concept
- pruritus
- Psoriasis Area and Severity Index
- psoriasis vulgaris
- sodium blood level
- therapy effect
- urea nitrogen blood level
- uric acid blood level
- very low calorie ketogenic diet
- visual analog scale
- weight loss program
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Aggressive weight-loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis: A proof-of-concept, single-arm, open-label clinical trial. / Castaldo, G.; Rastrelli, L.; Galdo, G.; Molettieri, P.; Rotondi Aufiero, F.; Cereda, E.
In: Nutrition, Vol. 74, 2020.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Aggressive weight-loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis: A proof-of-concept, single-arm, open-label clinical trial
AU - Castaldo, G.
AU - Rastrelli, L.
AU - Galdo, G.
AU - Molettieri, P.
AU - Rotondi Aufiero, F.
AU - Cereda, E.
N1 - Cited By :5 Export Date: 2 February 2021 CODEN: NUTRE Correspondence Address: Castaldo, G.; Nutriketo Lab A.O.R.N. San Giuseppe Moscati, Italy; email: lavoronep@yahoo.it Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; creatine kinase, 9001-15-4; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; sodium, 7440-23-5; urate, 1198-77-2, 3106-08-9, 59216-10-3 References: Armstrong, A.W., Psoriasis (2017) JAMA Dermatol, 153, p. 956; Di Meglio, P., Villanova, F., Nestle, F.O., Psoriasis (2014) Cold Spring Harb Perspect Med, 4; Budu-Aggrey, A., Brumpton, B., Tyrrell, J., Watkins, S., Modalsli, E.H., Celis-Morales, C., Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study (2019) PLoS Med, 16; Davidovici, B.B., Sattar, N., Prinz, J., Puig, L., Emery, P., Barker, J.N., Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and comorbid conditions (2010) J Invest Dermatol, 130, pp. 1785-1796; Gisondi, P., Del Giglio, M., Girolomoni, G., Considerations for systemic treatment of psoriasis in obese patients (2016) Am J Clin Dermatol, 17, pp. 609-615; Lynch, M., Ahern, T., Sweeney, C.M., Malara, A., Tobin, A.M., O'Shea, D., Adipokines, psoriasis, systemic inflammation, and endothelial dysfunction (2017) Int J Dermatol, 56, pp. 1103-1118; Cao, H., Adipocytokines in obesity and metabolic disease (2014) J Endocrinol, 220, pp. T47-T59; Alexopoulos, N., Katritsis, D., Raggi, P., Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis (2014) Atherosclerosis, 233, pp. 104-112; Kyriakou, A., Patsatsi, A., Sotiriadis, D., Goulis, D.G., Serum leptin, resistin, and adiponectin concentrations in psoriasis: a meta-analysis of observational studies (2017) Dermatology, 233, pp. 378-389; Kyriakou, A., Patsatsi, A., Sotiriadis, D., Goulis, D.G., Effects of treatment for psoriasis on circulating levels of leptin, adiponectin and resistin: a systematic review and meta-analysis (2018) Br J Dermatol, 179, pp. 273-281; Kocic, H., Damiani, G., Stamenkovic, B., Tirant, M., Jovic, A., Tiodorovic, D., Dietary compounds as potential modulators of microRNA expression in psoriasis (2019) Ther Adv Chronic Dis, 10; Gamret, A.C., Price, A., Fertig, R.M., Lev-Tov, H., Nichols, A.J., Complementary and alternative medicine therapies for psoriasis: a systematic review (2018) JAMA Dermatol, 154, pp. 1330-1337; Ford, A.R., Siegel, M., Bagel, J., Cordoro, K.M., Garg, A., Gottlieb, A., Dietary recommendations for adults with psoriasis or psoriatic arthritis from the medical board of the National Psoriasis Foundation: a systematic review (2018) JAMA Dermatol, 154, pp. 934-950; Mahil, S.K., McSweeney, S.M., Kloczko, E., McGowan, B., Barker, J.N., Smith, C.H., Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? 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E277; Adawi, M., Damiani, G., Bragazzi, N.L., Bridgewood, C., Pacifico, A., Conic, R.R.Z., The impact of intermittent fasting (Ramadan fasting) on psoriatic arthritis disease activity, enthesitis, and dactylitis: a multicentre study (2019) Nutrients, 11, p. E601; Ibrahim, G.H., Buch, M.H., Lawson, C., Waxman, R., Helliwell, P.S., Evaluation of an existing screening tool for psoriatic arthritis in people with psoriasis and the development of a new instrument: the Psoriasis Epidemiology Screening Tool (PEST) questionnaire (2009) Clin Exp Rheumatol, 27, pp. 469-474; Physical status: The use and interpretation of anthropometry. 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PY - 2020
Y1 - 2020
N2 - Objectives: A very low-calorie ketogenic diet (VLCKD) has been associated with a significant reduction in visceral adipose tissue and ketone bodies that likely possess antiinflammatory properties. We evaluated the efficacy of an aggressive weight-loss (WL) program with a ketogenic induction phase as first-line treatment for chronic plaque psoriasis. Methods: Adult patients who were overweight or obese and drug-naïve (i.e., never treated, excluding the use of topical emollients; n = 37; 30% men; age: 43.1 ± 13.8 y) with stable chronic plaque psoriasis underwent a 10-wk, 2-phase WL program consisting of a 4-wk protein-sparing, VLCKD (
AB - Objectives: A very low-calorie ketogenic diet (VLCKD) has been associated with a significant reduction in visceral adipose tissue and ketone bodies that likely possess antiinflammatory properties. We evaluated the efficacy of an aggressive weight-loss (WL) program with a ketogenic induction phase as first-line treatment for chronic plaque psoriasis. Methods: Adult patients who were overweight or obese and drug-naïve (i.e., never treated, excluding the use of topical emollients; n = 37; 30% men; age: 43.1 ± 13.8 y) with stable chronic plaque psoriasis underwent a 10-wk, 2-phase WL program consisting of a 4-wk protein-sparing, VLCKD (
KW - chronic plaque psoriasis
KW - ketogenic diet
KW - Mediterranean diet
KW - PASI
KW - Weight loss
KW - alanine aminotransferase
KW - aspartate aminotransferase
KW - creatine kinase
KW - lactate dehydrogenase
KW - milk protein
KW - sodium
KW - urate
KW - adult
KW - alanine aminotransferase blood level
KW - Article
KW - aspartate aminotransferase blood level
KW - asthenia
KW - bloating
KW - clinical article
KW - constipation
KW - creatine kinase blood level
KW - Dermatology Life Quality Index
KW - dietary compliance
KW - disease severity
KW - dizziness
KW - female
KW - headache
KW - heart palpitation
KW - human
KW - hunger
KW - lactate dehydrogenase blood level
KW - low calorie diet
KW - male
KW - muscle cramp
KW - nausea
KW - obesity
KW - open study
KW - priority journal
KW - proof of concept
KW - pruritus
KW - Psoriasis Area and Severity Index
KW - psoriasis vulgaris
KW - sodium blood level
KW - therapy effect
KW - urea nitrogen blood level
KW - uric acid blood level
KW - very low calorie ketogenic diet
KW - visual analog scale
KW - weight loss program
U2 - 10.1016/j.nut.2020.110757
DO - 10.1016/j.nut.2020.110757
M3 - Article
VL - 74
JO - Nutrition
JF - Nutrition
SN - 0899-9007
ER -