Aggressive weight-loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis: A proof-of-concept, single-arm, open-label clinical trial

G. Castaldo, L. Rastrelli, G. Galdo, P. Molettieri, F. Rotondi Aufiero, E. Cereda

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: A very low-calorie ketogenic diet (VLCKD) has been associated with a significant reduction in visceral adipose tissue and ketone bodies that likely possess antiinflammatory properties. We evaluated the efficacy of an aggressive weight-loss (WL) program with a ketogenic induction phase as first-line treatment for chronic plaque psoriasis. Methods: Adult patients who were overweight or obese and drug-naïve (i.e., never treated, excluding the use of topical emollients; n = 37; 30% men; age: 43.1 ± 13.8 y) with stable chronic plaque psoriasis underwent a 10-wk, 2-phase WL program consisting of a 4-wk protein-sparing, VLCKD (
Original languageEnglish
JournalNutrition
Volume74
DOIs
Publication statusPublished - 2020

Keywords

  • chronic plaque psoriasis
  • ketogenic diet
  • Mediterranean diet
  • PASI
  • Weight loss
  • alanine aminotransferase
  • aspartate aminotransferase
  • creatine kinase
  • lactate dehydrogenase
  • milk protein
  • sodium
  • urate
  • adult
  • alanine aminotransferase blood level
  • Article
  • aspartate aminotransferase blood level
  • asthenia
  • bloating
  • clinical article
  • constipation
  • creatine kinase blood level
  • Dermatology Life Quality Index
  • dietary compliance
  • disease severity
  • dizziness
  • female
  • headache
  • heart palpitation
  • human
  • hunger
  • lactate dehydrogenase blood level
  • low calorie diet
  • male
  • muscle cramp
  • nausea
  • obesity
  • open study
  • priority journal
  • proof of concept
  • pruritus
  • Psoriasis Area and Severity Index
  • psoriasis vulgaris
  • sodium blood level
  • therapy effect
  • urea nitrogen blood level
  • uric acid blood level
  • very low calorie ketogenic diet
  • visual analog scale
  • weight loss program

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