Aging brain and dementias: Changes in central opioids

G. Nappi, E. Sinforiani, E. Martignoni, F. Petraglia, F. Facchinetti, F. Rossi, A. R. Genazzani

Research output: Contribution to journalArticle


We evaluated the CSF levels of α-lipotropin (α-LPH), (J-endorphin (α-EP) and ACTH, which are three neuropeptides expressed by the same gene encoding for pro-opiomelanocortin, in various groups of demented patients including degenerative (presenile and senile Alzheimer-type dementia, ATD) and vascular (MID) forms. Twelve sex- and age-matched subjects were taken as controls. Our data indicate that ACTH levels are significantly reduced both in ATD and MID patients, while α-EP and α-LPH are significantly reduced only in ATD. The low CSF ACTH levels can be considered typical of all demented processes (both degenerative and vascular), while the reduction of α-EP and α-LPH in CSF could be due to adegenerative process of CNS.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalEuropean Neurology
Issue number4
Publication statusPublished - 1988


  • Aging brain
  • Dementia
  • Pro-opiomelanocortin-related peptides

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Nappi, G., Sinforiani, E., Martignoni, E., Petraglia, F., Facchinetti, F., Rossi, F., & Genazzani, A. R. (1988). Aging brain and dementias: Changes in central opioids. European Neurology, 28(4), 217-220.