Aging brain and dementias

Changes in central opioids

G. Nappi, E. Sinforiani, E. Martignoni, F. Petraglia, F. Facchinetti, F. Rossi, A. R. Genazzani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We evaluated the CSF levels of α-lipotropin (α-LPH), (J-endorphin (α-EP) and ACTH, which are three neuropeptides expressed by the same gene encoding for pro-opiomelanocortin, in various groups of demented patients including degenerative (presenile and senile Alzheimer-type dementia, ATD) and vascular (MID) forms. Twelve sex- and age-matched subjects were taken as controls. Our data indicate that ACTH levels are significantly reduced both in ATD and MID patients, while α-EP and α-LPH are significantly reduced only in ATD. The low CSF ACTH levels can be considered typical of all demented processes (both degenerative and vascular), while the reduction of α-EP and α-LPH in CSF could be due to adegenerative process of CNS.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalEuropean Neurology
Volume28
Issue number4
DOIs
Publication statusPublished - 1988

Fingerprint

Adrenocorticotropic Hormone
Opioid Analgesics
Dementia
Alzheimer Disease
Blood Vessels
Brain
beta-Lipotropin
Endorphins
Pro-Opiomelanocortin
Neuropeptides
Genes
Presenile And Senile Dementia

Keywords

  • Aging brain
  • Dementia
  • Pro-opiomelanocortin-related peptides

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Nappi, G., Sinforiani, E., Martignoni, E., Petraglia, F., Facchinetti, F., Rossi, F., & Genazzani, A. R. (1988). Aging brain and dementias: Changes in central opioids. European Neurology, 28(4), 217-220. https://doi.org/10.1159/000116270

Aging brain and dementias : Changes in central opioids. / Nappi, G.; Sinforiani, E.; Martignoni, E.; Petraglia, F.; Facchinetti, F.; Rossi, F.; Genazzani, A. R.

In: European Neurology, Vol. 28, No. 4, 1988, p. 217-220.

Research output: Contribution to journalArticle

Nappi, G, Sinforiani, E, Martignoni, E, Petraglia, F, Facchinetti, F, Rossi, F & Genazzani, AR 1988, 'Aging brain and dementias: Changes in central opioids', European Neurology, vol. 28, no. 4, pp. 217-220. https://doi.org/10.1159/000116270
Nappi G, Sinforiani E, Martignoni E, Petraglia F, Facchinetti F, Rossi F et al. Aging brain and dementias: Changes in central opioids. European Neurology. 1988;28(4):217-220. https://doi.org/10.1159/000116270
Nappi, G. ; Sinforiani, E. ; Martignoni, E. ; Petraglia, F. ; Facchinetti, F. ; Rossi, F. ; Genazzani, A. R. / Aging brain and dementias : Changes in central opioids. In: European Neurology. 1988 ; Vol. 28, No. 4. pp. 217-220.
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