Aging, inflammation and cancer

Research output: Contribution to journalReview article

Abstract

Aging is a key aspect of neoplasia at the level of cells, individuals and populations. Unrestrained expression and production of inflammatory mediators is a key feature of aging at the cellular and organism level. Inflammatory cells and mediators are a key component of the tumor microenvironment and drive tumor progression. Non-resolving smoldering inflammation increases the risk of cancer (the extrinsic pathway connecting inflammation and cancer). In the intrinsic pathway, genetic events that cause neoplasia (oncogenes and oncosupressor genes) orchestrate the construction of cancer-related inflammation. We argue that uncontrolled smoldering inflammation drives carcinogenesis in aging and acts as a common denominator linking aging and cancer.

Original languageEnglish
Pages (from-to)74-82
Number of pages9
JournalSeminars in Immunology
Volume40
DOIs
Publication statusPublished - Dec 1 2018

Keywords

  • Cancer
  • Immunosenescence
  • Inflammaging

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Aging, inflammation and cancer'. Together they form a unique fingerprint.

  • Cite this