Aging of the immune system as a prognostic factor for human longevity

Anis Larbi, Claudio Franceschi, Dawn Mazzatti, Rafael Solana, Anders Wikby, Graham Pawelec

Research output: Contribution to journalArticle


Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
Issue number2
Publication statusPublished - Apr 2008


ASJC Scopus subject areas

  • Physiology

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