Aging of the immune system as a prognostic factor for human longevity

Anis Larbi, Claudio Franceschi, Dawn Mazzatti, Rafael Solana, Anders Wikby, Graham Pawelec

Research output: Contribution to journalArticle

Abstract

Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalPhysiology
Volume23
Issue number2
DOIs
Publication statusPublished - Apr 2008

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ASJC Scopus subject areas

  • Physiology

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