Aging process affects a single class of dopamine receptors

M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

[3HSpiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalBrain Research
Volume202
Issue number2
DOIs
Publication statusPublished - Dec 8 1980

Fingerprint

Sulpiride
Dopamine Receptors
Corpus Striatum
Spiperone
Guanosine Triphosphate
Adenylyl Cyclases
Cyclic AMP
Binding Sites
Membranes

Keywords

  • adenylyl cyclase
  • aging
  • dopamine receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Memo, M., Lucchi, L., Spano, P. F., & Trabucchi, M. (1980). Aging process affects a single class of dopamine receptors. Brain Research, 202(2), 488-492. https://doi.org/10.1016/0006-8993(80)90161-4

Aging process affects a single class of dopamine receptors. / Memo, M.; Lucchi, L.; Spano, P. F.; Trabucchi, M.

In: Brain Research, Vol. 202, No. 2, 08.12.1980, p. 488-492.

Research output: Contribution to journalArticle

Memo, M, Lucchi, L, Spano, PF & Trabucchi, M 1980, 'Aging process affects a single class of dopamine receptors', Brain Research, vol. 202, no. 2, pp. 488-492. https://doi.org/10.1016/0006-8993(80)90161-4
Memo, M. ; Lucchi, L. ; Spano, P. F. ; Trabucchi, M. / Aging process affects a single class of dopamine receptors. In: Brain Research. 1980 ; Vol. 202, No. 2. pp. 488-492.
@article{4ae4d37a91eb447387c9a9b2537f3e37,
title = "Aging process affects a single class of dopamine receptors",
abstract = "[3HSpiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).",
keywords = "adenylyl cyclase, aging, dopamine receptor",
author = "M. Memo and L. Lucchi and Spano, {P. F.} and M. Trabucchi",
year = "1980",
month = "12",
day = "8",
doi = "10.1016/0006-8993(80)90161-4",
language = "English",
volume = "202",
pages = "488--492",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Aging process affects a single class of dopamine receptors

AU - Memo, M.

AU - Lucchi, L.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1980/12/8

Y1 - 1980/12/8

N2 - [3HSpiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).

AB - [3HSpiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).

KW - adenylyl cyclase

KW - aging

KW - dopamine receptor

UR - http://www.scopus.com/inward/record.url?scp=0019287253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019287253&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)90161-4

DO - 10.1016/0006-8993(80)90161-4

M3 - Article

C2 - 7437912

AN - SCOPUS:0019287253

VL - 202

SP - 488

EP - 492

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -