Aging process affects a single class of dopamine receptors

M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

[3HSpiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalBrain Research
Volume202
Issue number2
DOIs
Publication statusPublished - Dec 8 1980

Keywords

  • adenylyl cyclase
  • aging
  • dopamine receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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