Abstract
| Original language | English |
|---|---|
| Article number | 18064 |
| Journal | Sci. Rep. |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- adult
- article
- double blind procedure
- female
- healthy aging
- human
- human experiment
- major clinical study
- male
- medial prefrontal cortex
- randomized controlled trial
- reaction time
- theory of mind
- transcranial direct current stimulation
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Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study : Scientific Reports. / Adenzato, M.; Manenti, R.; Gobbi, E. et al.
In: Sci. Rep., Vol. 9, No. 1, 18064, 2019.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study
T2 - Scientific Reports
AU - Adenzato, M.
AU - Manenti, R.
AU - Gobbi, E.
AU - Enrici, I.
AU - Rusich, D.
AU - Cotelli, M.
N1 - Cited By :1 Export Date: 10 February 2020 Correspondence Address: Cotelli, M.; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliItaly; email: mcotelli@fatebenefratelli.eu Funding details: Università degli Studi di Torino, UNITO Funding text 1: Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy was supported by the Italian Ministry of Health (Ricerca Corrente). Mauro Adenzato and Ivan Enrici were supported by the University of Turin (“Ricerca scientifica finanziata dall’Università”). 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PY - 2019
Y1 - 2019
N2 - Aging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants. © 2019, The Author(s).
AB - Aging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants. © 2019, The Author(s).
KW - adult
KW - article
KW - double blind procedure
KW - female
KW - healthy aging
KW - human
KW - human experiment
KW - major clinical study
KW - male
KW - medial prefrontal cortex
KW - randomized controlled trial
KW - reaction time
KW - theory of mind
KW - transcranial direct current stimulation
U2 - 10.1038/s41598-019-54469-4
DO - 10.1038/s41598-019-54469-4
M3 - Article
VL - 9
JO - Sci. Rep.
JF - Sci. Rep.
SN - 2045-2322
IS - 1
M1 - 18064
ER -