Aging signaling pathways and circadian clock-dependent metabolic derangements

Maria Florencia Tevy, Jadwiga Giebultowicz, Zachary Pincus, Gianluigi Mazzoccoli, Manlio Vinciguerra

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume24
Issue number5
DOIs
Publication statusPublished - May 2013

Fingerprint

Circadian Clocks
Feeding Behavior
Circadian Rhythm
Reproduction
Homeostasis
Food

Keywords

  • Aging
  • Circadian clock
  • Flies
  • Glucose metabolism
  • Insulin
  • Mice
  • Nutrients

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Aging signaling pathways and circadian clock-dependent metabolic derangements. / Tevy, Maria Florencia; Giebultowicz, Jadwiga; Pincus, Zachary; Mazzoccoli, Gianluigi; Vinciguerra, Manlio.

In: Trends in Endocrinology and Metabolism, Vol. 24, No. 5, 05.2013, p. 229-237.

Research output: Contribution to journalArticle

Tevy, Maria Florencia ; Giebultowicz, Jadwiga ; Pincus, Zachary ; Mazzoccoli, Gianluigi ; Vinciguerra, Manlio. / Aging signaling pathways and circadian clock-dependent metabolic derangements. In: Trends in Endocrinology and Metabolism. 2013 ; Vol. 24, No. 5. pp. 229-237.
@article{220b5afee1a64daf9e328e65f59f44e2,
title = "Aging signaling pathways and circadian clock-dependent metabolic derangements",
abstract = "The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.",
keywords = "Aging, Circadian clock, Flies, Glucose metabolism, Insulin, Mice, Nutrients",
author = "Tevy, {Maria Florencia} and Jadwiga Giebultowicz and Zachary Pincus and Gianluigi Mazzoccoli and Manlio Vinciguerra",
year = "2013",
month = "5",
doi = "10.1016/j.tem.2012.12.002",
language = "English",
volume = "24",
pages = "229--237",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Aging signaling pathways and circadian clock-dependent metabolic derangements

AU - Tevy, Maria Florencia

AU - Giebultowicz, Jadwiga

AU - Pincus, Zachary

AU - Mazzoccoli, Gianluigi

AU - Vinciguerra, Manlio

PY - 2013/5

Y1 - 2013/5

N2 - The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

AB - The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

KW - Aging

KW - Circadian clock

KW - Flies

KW - Glucose metabolism

KW - Insulin

KW - Mice

KW - Nutrients

UR - http://www.scopus.com/inward/record.url?scp=84876989832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876989832&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2012.12.002

DO - 10.1016/j.tem.2012.12.002

M3 - Article

VL - 24

SP - 229

EP - 237

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 5

ER -