Agitation assessment in severe traumatic brain injury: Methodological and clinical issues

Elisabetta Angelino, Massimo Miglioretti, Anna Maria Zotti

Research output: Contribution to journalArticlepeer-review


The aim of this single case study was to evaluate the applicability of a graphic and statistical time-series analyses in the observation of an agitation disturbance in a 16-year-old patient who had sustained a severe traumatic brain injury. The agitation was measured using the Agitated Behaviour Scale. The experimental model was of the A-B type: phase A corresponded to the period of vegetative state, and phase B to the period following the reawakening from coma. The data were submitted to visual and statistical analysis by the split-middle trend line method, function of autocorrelation, and C statistic. The results show the different nature and frequency of the agitated behaviour during the vegetative state and after reawakening from coma. The application of a statistical analysis to establish whether the behavioural disturbance is random or a response to the environment allows the adoption of specific and potentially more efficacious treatments.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalBrain Injury
Issue number3
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Clinical Neurology


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