AgNOR distribution in serous tumours of the ovary.

F. A. Mauri, S. Scampini, D. Aldovini, S. Ferrero, M. Barbareschi, P. Dalla Palma

Research output: Contribution to journalArticlepeer-review


The present paper investigated the distribution of AgNOR in serous tumours of the ovary, with a particular attention to borderline lesion and carcinomas. AgNOR are classified as large AgNOR (LN) and small AgNOR (SN) and are counted separately in 100 nuclei for each tumor. Total number of AgNOR was also recorded (TN). The study shows that the mean values of LN, SN and TN increase from adenomas to borderline lesions and carcinomas, with highly significant differences (p less than 0.001). LN show the most impressive differences between borderline lesion and carcinomas, without overlap of values. The follow up of the patients is not long enough for any correlation between AgNOR counts and prognosis, but preliminary data suggest that high AgNOR counts in borderline tumors should be interpreted very cautiously, because they do not seem to have any correlation with a more aggressive behaviour.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
Issue number1081
Publication statusPublished - Sep 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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