Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF

Possible implication for brain progenitor cells' activation

Marco Fiore, Tiziana Amendola, Viviana Triaca, Paola Tirassa, Enrico Alleva, Luigi Aloe

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The condition of dominance or submission following agonistic encounters in the adult male mouse is known to differentially affect brain nerve growth factor, a neurotrophin playing a role in brain remodeling, in the fine tuning of behaviour and in the regulation of the basal forebrain cholinergic neurons. During development and adult life nerve growth factor regulates brain expression of neurotransmitters and the stimulation of progenitor cells (stem cells) which, under different external stimuli, may differentiate into neuronal and/or glial cells promoting the recovery of the injured brain. However, little information is available for the aged brain. Thus in the present study we investigated the effect of the social status ('dominance' vs. 'submission') in the aged mouse on the presence of nerve growth factor, brain-derived neurotrophic factor, choline acetyltransferase, neuropeptide Y and progenitor cells of selected brain regions. We found that aged dominant mice showed increased brain-derived neurotrophic factor in the subventricular zone and hippocampus and increased choline acetyltransferase in the septum and basal nuclei, which were associated with increased presence of progenitor cells in the subventricular zone. Conversely, in aged subordinate mice the data showed a marked brain increase in nerve growth factor in the subventricular zone and hippocampus, choline acetyltransferase in the septum and basal nuclei and neuropeptide Y in the hippocampus and parietal cortex. The possible functional implications of these findings are discussed.

Original languageEnglish
Pages (from-to)1455-1464
Number of pages10
JournalEuropean Journal of Neuroscience
Volume17
Issue number7
DOIs
Publication statusPublished - Apr 2003

Fingerprint

Brain-Derived Neurotrophic Factor
Nerve Growth Factor
Stem Cells
Brain
Choline O-Acetyltransferase
Lateral Ventricles
Hippocampus
Neuropeptide Y
Basal Ganglia
Social Dominance
Parietal Lobe
Cholinergic Neurons
Nerve Growth Factors
Neuroglia
Neurotransmitter Agents

Keywords

  • Ageing
  • BDNF
  • Neurogenesis
  • NGF
  • Progenitor cell
  • Stem cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF : Possible implication for brain progenitor cells' activation. / Fiore, Marco; Amendola, Tiziana; Triaca, Viviana; Tirassa, Paola; Alleva, Enrico; Aloe, Luigi.

In: European Journal of Neuroscience, Vol. 17, No. 7, 04.2003, p. 1455-1464.

Research output: Contribution to journalArticle

Fiore, Marco ; Amendola, Tiziana ; Triaca, Viviana ; Tirassa, Paola ; Alleva, Enrico ; Aloe, Luigi. / Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF : Possible implication for brain progenitor cells' activation. In: European Journal of Neuroscience. 2003 ; Vol. 17, No. 7. pp. 1455-1464.
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