Agreement between multi-dimensional and renal-specific response criteria in patients with juvenile systemic lupus erythematosus and renal disease

Nicolino Ruperto, A. Bazso, A. Pistorio, A. Ravelli, G. Filocamo, H. G. Hernandez Huirache, A. L. Rodriguez Lozano, A. B. Pringe, I. Vilca, A. Martini

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate change over time and level of agreement of renal-specific and multi-dimensional measures in juvenile systemic lupus erythematosus (SLE) with renal disease. Methods: An analysis was made of 205/557 children with baseline 24-hour proteinuria 2:05 g. Data were collected at baseline, 6-, 12- and 24-month intervals. Using the Systemic Lupus International Collaborating Clinics (SLICC) renal index (change in proteinuria and urine sediment) as gold standard, responsiveness and discriminative ability analyses were used to identify key renal and multi-dimensional disease activity and damage measures for the evaluation of response to therapy. We also evaluated the kappa agreement between SLICC renal index and PRINTO/ACR juvenile SLE criteria (change in proteinuria, physician and parents evaluations, disease activity, health related quality of life [HRQOL]). Results: Children with renal disease compared to children without renal disease, had a lower female rate and higher disease activity/response rate (p-values

Original languageEnglish
Pages (from-to)424-433
Number of pages10
JournalClinical and Experimental Rheumatology
Volume28
Issue number3
Publication statusPublished - 2010

Keywords

  • Core set
  • Disease activity
  • Juvenile systemic lupus erythematosus
  • Response to therapy

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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