Aids-related B-cell non-Hodgkin's lymphomas in direct blood-stream HIV-infected patients: Pathogenesis and differentiation features

M. Boiocchi, A. Carbone, V. De Re, R. Volpe, U. Tirelli

Research output: Contribution to journalArticle

Abstract

Six AIDS-related NHLs from direct blood-stream HIV-infected patients were characterised for clonality, maturation cell characteristics, activation of c-myc proto-oncogene and presence of HIV and EBV genomes. Four out of the 6 AIDS-related NHLs were of immature B-cell origin, contrasting with the lower frequency (2 out of 31) of immature B-cell NHLs occurring in HIV-negative patients. Moreover, 3 out of the 4 AIDS-related pre-B-NHLs were extranodal lymphomas. C-myc translocations or rearrangements were not found in Italian AIDS-related NHLs, unlike c-myc activation which had a high prevalence in the American series of AIDS-related NHLs. HIV and EBV are not, or only occasionally, directly involved in AIDS-related NHL pathogenesis since HIV genome has never been found in the neoplastic clones and EBV genome was detected in only I out of the 6 lymphomas analyzed.

Original languageEnglish
Pages (from-to)883-888
Number of pages6
JournalInternational Journal of Cancer
Volume45
Issue number5
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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