Abstract
Kaposi's sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. Apart from this, the increased severity of this neoplasm in patients infected with HIV may be due to HIV-derived tat protein synergising with cytokines and chemokines with angiogenetic activity. Finally, the lower incidence of the malignancy in females may be related to a protective effect of human chorionic gonadotrophin (HCG), presumably mediated by its effect on microvasculature. All these advances suggest new possibilities in the management of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 311-315 |
| Number of pages | 5 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 18 |
| Issue number | 3 |
| Publication status | Published - Sep 1999 |
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Keywords
- AIDS
- Angiogenic factors
- HHV-8
- Hormones
- Kaposi's sarcoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Aids-related Kaposi's sarcoma : Principal pathogenic mechanisms. / Silvestris, N.
In: Journal of Experimental and Clinical Cancer Research, Vol. 18, No. 3, 09.1999, p. 311-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aids-related Kaposi's sarcoma
T2 - Principal pathogenic mechanisms
AU - Silvestris, N.
PY - 1999/9
Y1 - 1999/9
N2 - Kaposi's sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. Apart from this, the increased severity of this neoplasm in patients infected with HIV may be due to HIV-derived tat protein synergising with cytokines and chemokines with angiogenetic activity. Finally, the lower incidence of the malignancy in females may be related to a protective effect of human chorionic gonadotrophin (HCG), presumably mediated by its effect on microvasculature. All these advances suggest new possibilities in the management of the disease.
AB - Kaposi's sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. Apart from this, the increased severity of this neoplasm in patients infected with HIV may be due to HIV-derived tat protein synergising with cytokines and chemokines with angiogenetic activity. Finally, the lower incidence of the malignancy in females may be related to a protective effect of human chorionic gonadotrophin (HCG), presumably mediated by its effect on microvasculature. All these advances suggest new possibilities in the management of the disease.
KW - AIDS
KW - Angiogenic factors
KW - HHV-8
KW - Hormones
KW - Kaposi's sarcoma
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UR - http://www.scopus.com/inward/citedby.url?scp=0032712654&partnerID=8YFLogxK
M3 - Article
C2 - 10606175
AN - SCOPUS:0032712654
VL - 18
SP - 311
EP - 315
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 3
ER -