Aids-related Kaposi's sarcoma: Principal pathogenic mechanisms

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Abstract

Kaposi's sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. Apart from this, the increased severity of this neoplasm in patients infected with HIV may be due to HIV-derived tat protein synergising with cytokines and chemokines with angiogenetic activity. Finally, the lower incidence of the malignancy in females may be related to a protective effect of human chorionic gonadotrophin (HCG), presumably mediated by its effect on microvasculature. All these advances suggest new possibilities in the management of the disease.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume18
Issue number3
Publication statusPublished - Sep 1999

Keywords

  • AIDS
  • Angiogenic factors
  • HHV-8
  • Hormones
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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