Aids-related plasmablastic lymphomas of the oral cavity and jaws: A diagnostic dilemma

Antonino Carbone, Alfio Ferlito, Gianluca Gaidano, Alessandra Rinaldo, Annunziata Gloghini, Harald Stein

Research output: Contribution to journalArticle

Abstract

Acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphomas are highly pleomorphic in their clinical, pathological, and biological features. Recent investigations have led to the identification of a particular type of AIDS-related non-Hodgkin's lymphomas presenting in the oral cavity and jaws. This novel category of AIDS-related non-Hodgkin's lymphomas derives from B-cells and has been defined as plasmablastic lymphoma on the basis of its morphological and immunophenotypic features. Clinically, AIDS-related plasmablastic lymphoma is generally limited to the oral cavity at the time of diagnosis, although extension to distant sites frequently occurs at a later stage. Histologically, AIDS-related plasmablastic lymphoma is composed of a monomorphic and cohesive pattern of plasmablasts with basophilic cytoplasm. Phenotypically, AIDS-related plasmablastic lymphoma fails to express the most common B-cell-associated surface antigens, whereas it consistently expresses high levels of plasma cell-associated markers, including VS38c and CD138/syndecan-1. For the purpose of differential diagnosis, the morphological and immunophenotypic peculiarities of AIDS- related plasmablastic lymphoma clearly distinguish these lymphomas from other categories of AIDS-related non-Hodgkin's lymphomas, as well as from undifferentiated large cell carcinomas.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume108
Issue number1
Publication statusPublished - 1999

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Jaw
Mouth
Acquired Immunodeficiency Syndrome
Non-Hodgkin's Lymphoma
B-Lymphocytes
Syndecan-1
Large Cell Carcinoma
Plasmablastic Lymphoma
Surface Antigens
Plasma Cells
Lymphoma
Cytoplasm
Differential Diagnosis

ASJC Scopus subject areas

  • Otorhinolaryngology

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Aids-related plasmablastic lymphomas of the oral cavity and jaws : A diagnostic dilemma. / Carbone, Antonino; Ferlito, Alfio; Gaidano, Gianluca; Rinaldo, Alessandra; Gloghini, Annunziata; Stein, Harald.

In: Annals of Otology, Rhinology and Laryngology, Vol. 108, No. 1, 1999, p. 95-99.

Research output: Contribution to journalArticle

Carbone, A, Ferlito, A, Gaidano, G, Rinaldo, A, Gloghini, A & Stein, H 1999, 'Aids-related plasmablastic lymphomas of the oral cavity and jaws: A diagnostic dilemma', Annals of Otology, Rhinology and Laryngology, vol. 108, no. 1, pp. 95-99.
Carbone, Antonino ; Ferlito, Alfio ; Gaidano, Gianluca ; Rinaldo, Alessandra ; Gloghini, Annunziata ; Stein, Harald. / Aids-related plasmablastic lymphomas of the oral cavity and jaws : A diagnostic dilemma. In: Annals of Otology, Rhinology and Laryngology. 1999 ; Vol. 108, No. 1. pp. 95-99.
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