Abstract
DNA methylation is a potential pathway linking air pollution to disease. Studies indicate that psychological functioning modifies the association between pollution and morbidity. The authors estimated the association of DNA methylation with ambient particulate matter less than 2.5 μm in diameter (PM 2.5) and black carbon, using mixed models. DNA methylation of the inducible nitric oxide synthase gene, iNOS, and the glucocorticoid receptor gene, GCR, was measured by quantitative polymerase chain reaction pyrosequencing of 1,377 blood samples from 699 elderly male participants in the VA Normative Aging Study (1999-2009). The authors also investigated whether this association was modified by psychological factors including optimism or pessimism, anxiety, and depression. iNOS methylation was decreased after acute exposure to both black carbon and PM 2.5. A 1-μg/m 3 increase in exposure to black carbon in the 4 hours preceding the clinical examination was associated with a 0.9 decrease in 5-methylcytosine (95 CI: 0.4, 1.4) in iNOS, and a 10-μg/m 3 increase in exposure to PM 2.5 was associated with a 0.6 decrease in 5-methylcytosine (95 CI: 0.03, 1.1) in iNOS. Participants with low optimism and high anxiety had associations that were 34 times larger than those with high optimism or low anxiety. GCR methylation was not associated with particulate air pollution exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 224-232 |
| Number of pages | 9 |
| Journal | American Journal of Epidemiology |
| Volume | 176 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2012 |
Fingerprint
Keywords
- air pollution
- DNA methylation
- psychology
ASJC Scopus subject areas
- Epidemiology
Cite this
Air pollution and DNA methylation : Interaction by psychological factors in the va normative aging study. / Madrigano, Jaime; Baccarelli, Andrea; Mittleman, Murray A.; Sparrow, David; Spiro, Avron; Vokonas, Pantel S.; Cantone, Laura; Kubzansky, Laura; Schwartz, Joel.
In: American Journal of Epidemiology, Vol. 176, No. 3, 08.2012, p. 224-232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Air pollution and DNA methylation
T2 - Interaction by psychological factors in the va normative aging study
AU - Madrigano, Jaime
AU - Baccarelli, Andrea
AU - Mittleman, Murray A.
AU - Sparrow, David
AU - Spiro, Avron
AU - Vokonas, Pantel S.
AU - Cantone, Laura
AU - Kubzansky, Laura
AU - Schwartz, Joel
PY - 2012/8
Y1 - 2012/8
N2 - DNA methylation is a potential pathway linking air pollution to disease. Studies indicate that psychological functioning modifies the association between pollution and morbidity. The authors estimated the association of DNA methylation with ambient particulate matter less than 2.5 μm in diameter (PM 2.5) and black carbon, using mixed models. DNA methylation of the inducible nitric oxide synthase gene, iNOS, and the glucocorticoid receptor gene, GCR, was measured by quantitative polymerase chain reaction pyrosequencing of 1,377 blood samples from 699 elderly male participants in the VA Normative Aging Study (1999-2009). The authors also investigated whether this association was modified by psychological factors including optimism or pessimism, anxiety, and depression. iNOS methylation was decreased after acute exposure to both black carbon and PM 2.5. A 1-μg/m 3 increase in exposure to black carbon in the 4 hours preceding the clinical examination was associated with a 0.9 decrease in 5-methylcytosine (95 CI: 0.4, 1.4) in iNOS, and a 10-μg/m 3 increase in exposure to PM 2.5 was associated with a 0.6 decrease in 5-methylcytosine (95 CI: 0.03, 1.1) in iNOS. Participants with low optimism and high anxiety had associations that were 34 times larger than those with high optimism or low anxiety. GCR methylation was not associated with particulate air pollution exposure.
AB - DNA methylation is a potential pathway linking air pollution to disease. Studies indicate that psychological functioning modifies the association between pollution and morbidity. The authors estimated the association of DNA methylation with ambient particulate matter less than 2.5 μm in diameter (PM 2.5) and black carbon, using mixed models. DNA methylation of the inducible nitric oxide synthase gene, iNOS, and the glucocorticoid receptor gene, GCR, was measured by quantitative polymerase chain reaction pyrosequencing of 1,377 blood samples from 699 elderly male participants in the VA Normative Aging Study (1999-2009). The authors also investigated whether this association was modified by psychological factors including optimism or pessimism, anxiety, and depression. iNOS methylation was decreased after acute exposure to both black carbon and PM 2.5. A 1-μg/m 3 increase in exposure to black carbon in the 4 hours preceding the clinical examination was associated with a 0.9 decrease in 5-methylcytosine (95 CI: 0.4, 1.4) in iNOS, and a 10-μg/m 3 increase in exposure to PM 2.5 was associated with a 0.6 decrease in 5-methylcytosine (95 CI: 0.03, 1.1) in iNOS. Participants with low optimism and high anxiety had associations that were 34 times larger than those with high optimism or low anxiety. GCR methylation was not associated with particulate air pollution exposure.
KW - air pollution
KW - DNA methylation
KW - psychology
UR - http://www.scopus.com/inward/record.url?scp=84864423021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864423021&partnerID=8YFLogxK
U2 - 10.1093/aje/kwr523
DO - 10.1093/aje/kwr523
M3 - Article
C2 - 22798479
AN - SCOPUS:84864423021
VL - 176
SP - 224
EP - 232
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 3
ER -