Air pollution and lung cancer incidence in 17 European cohorts: Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Ole Raaschou-Nielsen, Zorana J. Andersen, Rob Beelen, Evangelia Samoli, Massimo Stafoggia, Gudrun Weinmayr, Barbara Hoffmann, Paul Fischer, Mark J. Nieuwenhuijsen, Bert Brunekreef, Wei W. Xun, Klea Katsouyanni, Konstantina Dimakopoulou, Johan Sommar, Bertil Forsberg, Lars Modig, Anna Oudin, Bente Oftedal, Per E. Schwarze, Per NafstadUlf De Faire, Nancy L. Pedersen, Claes Göran Östenson, Laura Fratiglioni, Johanna Penell, Michal Korek, Göran Pershagen, Kirsten T. Eriksen, Mette Sørensen, Anne Tjønneland, Thomas Ellermann, Marloes Eeftens, Petra H. Peeters, Kees Meliefste, Meng Wang, Bas Bueno-de-Mesquita, Timothy J. Key, Kees de Hoogh, Hans Concin, Gabriele Nagel, Alice Vilier, Sara Grioni, Vittorio Krogh, Ming Yi Tsai, Fulvio Ricceri, Carlotta Sacerdote, Claudia Galassi, Enrica Migliore, Andrea Ranzi, Giulia Cesaroni, Chiara Badaloni, Francesco Forastiere, Ibon Tamayo, Pilar Amiano, Miren Dorronsoro, Antonia Trichopoulou, Christina Bamia, Paolo Vineis, Gerard Hoek

Research output: Contribution to journalArticle

651 Citations (Scopus)

Abstract

Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. Findings: The 312-944 cohort members contributed 4-013-131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m3). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m3. The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m3) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). Interpretation: Particulate matter air pollution contributes to lung cancer incidence in Europe. Funding: European Community's Seventh Framework Programme.

Original languageEnglish
Pages (from-to)813-822
Number of pages10
JournalThe Lancet Oncology
Volume14
Issue number9
DOIs
Publication statusPublished - Aug 2013

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Air Pollution
Lung Neoplasms
Cohort Studies
Incidence
Nitrogen Oxides
Particulate Matter
Meta-Analysis
Geographic Mapping
Soot
European Union
Proportional Hazards Models
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Air pollution and lung cancer incidence in 17 European cohorts : Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). / Raaschou-Nielsen, Ole; Andersen, Zorana J.; Beelen, Rob; Samoli, Evangelia; Stafoggia, Massimo; Weinmayr, Gudrun; Hoffmann, Barbara; Fischer, Paul; Nieuwenhuijsen, Mark J.; Brunekreef, Bert; Xun, Wei W.; Katsouyanni, Klea; Dimakopoulou, Konstantina; Sommar, Johan; Forsberg, Bertil; Modig, Lars; Oudin, Anna; Oftedal, Bente; Schwarze, Per E.; Nafstad, Per; De Faire, Ulf; Pedersen, Nancy L.; Östenson, Claes Göran; Fratiglioni, Laura; Penell, Johanna; Korek, Michal; Pershagen, Göran; Eriksen, Kirsten T.; Sørensen, Mette; Tjønneland, Anne; Ellermann, Thomas; Eeftens, Marloes; Peeters, Petra H.; Meliefste, Kees; Wang, Meng; Bueno-de-Mesquita, Bas; Key, Timothy J.; de Hoogh, Kees; Concin, Hans; Nagel, Gabriele; Vilier, Alice; Grioni, Sara; Krogh, Vittorio; Tsai, Ming Yi; Ricceri, Fulvio; Sacerdote, Carlotta; Galassi, Claudia; Migliore, Enrica; Ranzi, Andrea; Cesaroni, Giulia; Badaloni, Chiara; Forastiere, Francesco; Tamayo, Ibon; Amiano, Pilar; Dorronsoro, Miren; Trichopoulou, Antonia; Bamia, Christina; Vineis, Paolo; Hoek, Gerard.

In: The Lancet Oncology, Vol. 14, No. 9, 08.2013, p. 813-822.

Research output: Contribution to journalArticle

Raaschou-Nielsen, O, Andersen, ZJ, Beelen, R, Samoli, E, Stafoggia, M, Weinmayr, G, Hoffmann, B, Fischer, P, Nieuwenhuijsen, MJ, Brunekreef, B, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Sommar, J, Forsberg, B, Modig, L, Oudin, A, Oftedal, B, Schwarze, PE, Nafstad, P, De Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pershagen, G, Eriksen, KT, Sørensen, M, Tjønneland, A, Ellermann, T, Eeftens, M, Peeters, PH, Meliefste, K, Wang, M, Bueno-de-Mesquita, B, Key, TJ, de Hoogh, K, Concin, H, Nagel, G, Vilier, A, Grioni, S, Krogh, V, Tsai, MY, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Tamayo, I, Amiano, P, Dorronsoro, M, Trichopoulou, A, Bamia, C, Vineis, P & Hoek, G 2013, 'Air pollution and lung cancer incidence in 17 European cohorts: Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)', The Lancet Oncology, vol. 14, no. 9, pp. 813-822. https://doi.org/10.1016/S1470-2045(13)70279-1
Raaschou-Nielsen, Ole ; Andersen, Zorana J. ; Beelen, Rob ; Samoli, Evangelia ; Stafoggia, Massimo ; Weinmayr, Gudrun ; Hoffmann, Barbara ; Fischer, Paul ; Nieuwenhuijsen, Mark J. ; Brunekreef, Bert ; Xun, Wei W. ; Katsouyanni, Klea ; Dimakopoulou, Konstantina ; Sommar, Johan ; Forsberg, Bertil ; Modig, Lars ; Oudin, Anna ; Oftedal, Bente ; Schwarze, Per E. ; Nafstad, Per ; De Faire, Ulf ; Pedersen, Nancy L. ; Östenson, Claes Göran ; Fratiglioni, Laura ; Penell, Johanna ; Korek, Michal ; Pershagen, Göran ; Eriksen, Kirsten T. ; Sørensen, Mette ; Tjønneland, Anne ; Ellermann, Thomas ; Eeftens, Marloes ; Peeters, Petra H. ; Meliefste, Kees ; Wang, Meng ; Bueno-de-Mesquita, Bas ; Key, Timothy J. ; de Hoogh, Kees ; Concin, Hans ; Nagel, Gabriele ; Vilier, Alice ; Grioni, Sara ; Krogh, Vittorio ; Tsai, Ming Yi ; Ricceri, Fulvio ; Sacerdote, Carlotta ; Galassi, Claudia ; Migliore, Enrica ; Ranzi, Andrea ; Cesaroni, Giulia ; Badaloni, Chiara ; Forastiere, Francesco ; Tamayo, Ibon ; Amiano, Pilar ; Dorronsoro, Miren ; Trichopoulou, Antonia ; Bamia, Christina ; Vineis, Paolo ; Hoek, Gerard. / Air pollution and lung cancer incidence in 17 European cohorts : Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). In: The Lancet Oncology. 2013 ; Vol. 14, No. 9. pp. 813-822.
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title = "Air pollution and lung cancer incidence in 17 European cohorts: Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)",
abstract = "Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. Findings: The 312-944 cohort members contributed 4-013-131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95{\%} CI 1·03-1·45] per 10 μg/m3). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m3. The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m3) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). Interpretation: Particulate matter air pollution contributes to lung cancer incidence in Europe. Funding: European Community's Seventh Framework Programme.",
author = "Ole Raaschou-Nielsen and Andersen, {Zorana J.} and Rob Beelen and Evangelia Samoli and Massimo Stafoggia and Gudrun Weinmayr and Barbara Hoffmann and Paul Fischer and Nieuwenhuijsen, {Mark J.} and Bert Brunekreef and Xun, {Wei W.} and Klea Katsouyanni and Konstantina Dimakopoulou and Johan Sommar and Bertil Forsberg and Lars Modig and Anna Oudin and Bente Oftedal and Schwarze, {Per E.} and Per Nafstad and {De Faire}, Ulf and Pedersen, {Nancy L.} and {\"O}stenson, {Claes G{\"o}ran} and Laura Fratiglioni and Johanna Penell and Michal Korek and G{\"o}ran Pershagen and Eriksen, {Kirsten T.} and Mette S{\o}rensen and Anne Tj{\o}nneland and Thomas Ellermann and Marloes Eeftens and Peeters, {Petra H.} and Kees Meliefste and Meng Wang and Bas Bueno-de-Mesquita and Key, {Timothy J.} and {de Hoogh}, Kees and Hans Concin and Gabriele Nagel and Alice Vilier and Sara Grioni and Vittorio Krogh and Tsai, {Ming Yi} and Fulvio Ricceri and Carlotta Sacerdote and Claudia Galassi and Enrica Migliore and Andrea Ranzi and Giulia Cesaroni and Chiara Badaloni and Francesco Forastiere and Ibon Tamayo and Pilar Amiano and Miren Dorronsoro and Antonia Trichopoulou and Christina Bamia and Paolo Vineis and Gerard Hoek",
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month = "8",
doi = "10.1016/S1470-2045(13)70279-1",
language = "English",
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pages = "813--822",
journal = "The Lancet Oncology",
issn = "1470-2045",
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TY - JOUR

T1 - Air pollution and lung cancer incidence in 17 European cohorts

T2 - Prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

AU - Raaschou-Nielsen, Ole

AU - Andersen, Zorana J.

AU - Beelen, Rob

AU - Samoli, Evangelia

AU - Stafoggia, Massimo

AU - Weinmayr, Gudrun

AU - Hoffmann, Barbara

AU - Fischer, Paul

AU - Nieuwenhuijsen, Mark J.

AU - Brunekreef, Bert

AU - Xun, Wei W.

AU - Katsouyanni, Klea

AU - Dimakopoulou, Konstantina

AU - Sommar, Johan

AU - Forsberg, Bertil

AU - Modig, Lars

AU - Oudin, Anna

AU - Oftedal, Bente

AU - Schwarze, Per E.

AU - Nafstad, Per

AU - De Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Fratiglioni, Laura

AU - Penell, Johanna

AU - Korek, Michal

AU - Pershagen, Göran

AU - Eriksen, Kirsten T.

AU - Sørensen, Mette

AU - Tjønneland, Anne

AU - Ellermann, Thomas

AU - Eeftens, Marloes

AU - Peeters, Petra H.

AU - Meliefste, Kees

AU - Wang, Meng

AU - Bueno-de-Mesquita, Bas

AU - Key, Timothy J.

AU - de Hoogh, Kees

AU - Concin, Hans

AU - Nagel, Gabriele

AU - Vilier, Alice

AU - Grioni, Sara

AU - Krogh, Vittorio

AU - Tsai, Ming Yi

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Galassi, Claudia

AU - Migliore, Enrica

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Badaloni, Chiara

AU - Forastiere, Francesco

AU - Tamayo, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Vineis, Paolo

AU - Hoek, Gerard

PY - 2013/8

Y1 - 2013/8

N2 - Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. Findings: The 312-944 cohort members contributed 4-013-131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m3). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m3. The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m3) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). Interpretation: Particulate matter air pollution contributes to lung cancer incidence in Europe. Funding: European Community's Seventh Framework Programme.

AB - Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. Findings: The 312-944 cohort members contributed 4-013-131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m3). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m3. The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m3) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). Interpretation: Particulate matter air pollution contributes to lung cancer incidence in Europe. Funding: European Community's Seventh Framework Programme.

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