Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: A repeated-measure study

Lifang Hou, Sheng Wang, Chang Dou, Xiao Zhang, Yue Yu, Yinan Zheng, Umakanth Avula, Mirjam Hoxha, Anaité Díaz, John McCracken, Francesco Barretta, Barbara Marinelli, Pier Alberto Bertazzi, Joel Schwartz, Andrea A. Baccarelli

Research output: Contribution to journalArticle

Abstract

Background: Ambient particulate matter (PM) exposure has been associated with short- and long-term effects on cardiovascular disease (CVD). Telomere length (TL) is a biomarker of CVD risk that is modified by inflammation and oxidative stress, two key pathways for PM effects. Whether PM exposure modifies TL is largely unexplored. Objectives: To investigate effects of PM on blood TL in a highly-exposed population. Methods: We measured blood TL in 120 blood samples from truck drivers and 120 blood samples from office workers in Beijing, China. We measured personal PM2.5 and Elemental Carbon (EC, a tracer of traffic particles) using light-weight monitors. Ambient PM10 was obtained from local monitoring stations. We used covariate-adjusted regression models to estimate percent changes in TL per an interquartile-range increase in exposure. Results: Covariate-adjusted TL was higher in drivers (mean=0.87, 95%CI: 0.74; 1.03) than in office workers (mean=0.79, 95%CI: 0.67; 0.93; p=0.001). In all participants combined, TL increased in association with personal PM2.5 (+5.2%, 95%CI: 1.5; 9.1; p=0.007), personal EC (+4.9%, 95%CI: 1.2; 8.8; p=0.01), and ambient PM10 (+7.7%, 95%CI: 3.7; 11.9; p10 over the 14days before the examinations was significantly associated with shorter TL (-9.9%, 95%CI: -17.6; -1.5; p=0.02). Conclusions: Short-term exposure to ambient PM is associated with increased blood TL, consistent with TL roles during acute inflammatory responses. Longer exposures may shorten TL as expected after prolonged pro-oxidant exposures. The observed TL alterations may participate in the biological pathways of short- and long-term PM effects.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalEnvironment International
Volume48
DOIs
Publication statusPublished - Nov 1 2012

Keywords

  • China
  • Particulate matter
  • Personal monitoring
  • Telomere length
  • Traffic pollution

ASJC Scopus subject areas

  • Environmental Science(all)

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    Hou, L., Wang, S., Dou, C., Zhang, X., Yu, Y., Zheng, Y., Avula, U., Hoxha, M., Díaz, A., McCracken, J., Barretta, F., Marinelli, B., Bertazzi, P. A., Schwartz, J., & Baccarelli, A. A. (2012). Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: A repeated-measure study. Environment International, 48, 71-77. https://doi.org/10.1016/j.envint.2012.06.020