Air Pollution Impact on Pregnancy Outcomes in Como, Italy

Matteo Capobussi, Roberto Tettamanti, Luca Marcolin, Luca Piovesan, Silvia Bronzin, Maria Elena Gattoni, Ilaria Polloni, Giuliana Sabatino, Carlo A. Tersalvi, Francesco Auxilia, Silvana Castaldi

Research output: Contribution to journalArticlepeer-review


Objective: This retrospective observational study investigates the association between maternal exposure to air pollutants and pregnancy adverse outcomes in low urbanization areas. Methods: We used multivariate regression analysis to estimate, in the Como province (2005-2012), the effects of NO x, NO 2, SO 2, O 3, CO, and PM 10 on low birth weight (LBW), babies small for gestational age (SGA), and preterm birth (PTB). Results: PTB was inversely associated with high (5.5μg/m 3) exposure to SO 2 (adjusted odds ratio [aOR]=0.74, 95% confidence interval [95% CI]=0.58-0.95) and to CO (1.8mg/m 3, aOR=0.84, CI=0.72-0.99). PTB risk increased with second trimester exposure to NO x (118.3μg/m 3, aOR=1.53, CI=1.25-1.87), while LBW risk increased with third trimester PM 10 (56.1μg/m 3, aOR=1.44, CI=1.03-2.02). SGA was inversely associated with third trimester NO x (115.8μg/m 3, aOR=0.89, CI=0.79-0.99). Conclusions: Exposure to SO 2 and CO seems to postpone delivery: A longer gestation could compensate for maternal hypoxemic-hypoxic damage.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Issue number1
Publication statusPublished - Jan 1 2016


  • Air pollution
  • low birth weight
  • pregnancy
  • preterm birth
  • small for gestational age

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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