Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI

Roberto Bergamaschi, Andrea Cortese, Anna Pichiecchio, Francesca Gigli Berzolari, Paola Borrelli, Giulia Mallucci, Valentina Bollati, Alfredo Romani, Guido Nosari, Silvia Villa, Cristina Montomoli

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role.

OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10).

METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects.

RESULTS: PM10levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16%, 21%, 24%, 25%, and 21%, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001).

CONCLUSION: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.

Original languageEnglish
Pages (from-to)1352458517726866
JournalMultiple Sclerosis
DOIs
Publication statusE-pub ahead of print - Aug 1 2017

Fingerprint

Air Pollution
Gadolinium
Multiple Sclerosis
Magnetic Resonance Imaging
Brain
Particulate Matter

Keywords

  • Journal Article

Cite this

Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI. / Bergamaschi, Roberto; Cortese, Andrea; Pichiecchio, Anna; Berzolari, Francesca Gigli; Borrelli, Paola; Mallucci, Giulia; Bollati, Valentina; Romani, Alfredo; Nosari, Guido; Villa, Silvia; Montomoli, Cristina.

In: Multiple Sclerosis, 01.08.2017, p. 1352458517726866.

Research output: Contribution to journalArticle

Bergamaschi, R, Cortese, A, Pichiecchio, A, Berzolari, FG, Borrelli, P, Mallucci, G, Bollati, V, Romani, A, Nosari, G, Villa, S & Montomoli, C 2017, 'Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI', Multiple Sclerosis, pp. 1352458517726866. https://doi.org/10.1177/1352458517726866
Bergamaschi, Roberto ; Cortese, Andrea ; Pichiecchio, Anna ; Berzolari, Francesca Gigli ; Borrelli, Paola ; Mallucci, Giulia ; Bollati, Valentina ; Romani, Alfredo ; Nosari, Guido ; Villa, Silvia ; Montomoli, Cristina. / Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI. In: Multiple Sclerosis. 2017 ; pp. 1352458517726866.
@article{1d33f0ddcbff4523bb337ee19a51ebb1,
title = "Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI",
abstract = "BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role.OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10).METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34{\%} with (Gd+MRI) and 66{\%} without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects.RESULTS: PM10levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16{\%}, 21{\%}, 24{\%}, 25{\%}, and 21{\%}, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001).CONCLUSION: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.",
keywords = "Journal Article",
author = "Roberto Bergamaschi and Andrea Cortese and Anna Pichiecchio and Berzolari, {Francesca Gigli} and Paola Borrelli and Giulia Mallucci and Valentina Bollati and Alfredo Romani and Guido Nosari and Silvia Villa and Cristina Montomoli",
year = "2017",
month = "8",
day = "1",
doi = "10.1177/1352458517726866",
language = "English",
pages = "1352458517726866",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI

AU - Bergamaschi, Roberto

AU - Cortese, Andrea

AU - Pichiecchio, Anna

AU - Berzolari, Francesca Gigli

AU - Borrelli, Paola

AU - Mallucci, Giulia

AU - Bollati, Valentina

AU - Romani, Alfredo

AU - Nosari, Guido

AU - Villa, Silvia

AU - Montomoli, Cristina

PY - 2017/8/1

Y1 - 2017/8/1

N2 - BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role.OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10).METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects.RESULTS: PM10levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16%, 21%, 24%, 25%, and 21%, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001).CONCLUSION: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.

AB - BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role.OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10).METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects.RESULTS: PM10levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16%, 21%, 24%, 25%, and 21%, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001).CONCLUSION: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.

KW - Journal Article

U2 - 10.1177/1352458517726866

DO - 10.1177/1352458517726866

M3 - Article

C2 - 28805546

SP - 1352458517726866

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

ER -