Air pollution is associated to the multiple sclerosis inflammatory activity as measured by brain MRI

Roberto Bergamaschi, Andrea Cortese, Anna Pichiecchio, Francesca Gigli Berzolari, Paola Borrelli, Giulia Mallucci, Valentina Bollati, Alfredo Romani, Guido Nosari, Silvia Villa, Cristina Montomoli

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional factors might play a role.

OBJECTIVE: To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters with diameter less than 10 μm (PM10).

METHODS: We analyzed from 52 remitting MS patients 226 brain MRIs, 34% with (Gd+MRI) and 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily recording of PM10in the 30 days before MRI examination was obtained by monitors depending on the residence of subjects.

RESULTS: PM10levels in the 5, 10, 15, 20, and 25 days before brain MRIs were higher (plus 16%, 21%, 24%, 25%, and 21%, respectively) with reference to Gd+MRI versus Gd-MRI. There was a significant association between Gd+MRI and PM10levels ( p = 0.013), independent of immune therapies, smoker status, and season. In patients who had two repeated MRIs with opposite outcomes (Gd-MRI and Gd+MRI), PM10levels were strongly higher in concurrence with Gd+MRI ( p < 0.0001).

CONCLUSION: Our findings suggest that air pollution may be a risk factor for MS favoring inflammatory exacerbations.

Original languageEnglish
Pages (from-to)1352458517726866
JournalMultiple Sclerosis
DOIs
Publication statusE-pub ahead of print - Aug 1 2017

Keywords

  • Journal Article

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