Airway bacterial colonization

The missing link between COPD and cardiovascular events?

Salvatore Fuschillo, Michele Martucci, Claudio F. Donner, Giovanni Balzano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and, according to the World Health Organization, its prevalence will double by 2020. COPD is a chronic inflammatory disease of the lung characterized by poorly reversible airflow limitation and, frequently, by extrapulmonary manifestations. In particular, the cardiovascular manifestations are responsible for high morbidity and mortality. Methods and results: A systematic literature search was performed of studies published in Medline until December 2010, using the key-words: COPD, bacterial colonization, COPD exacerbation, atherosclerosis, systemic inflammation, cardiovascular event and risk factors. In addition to the studies identified in the primary search, reference lists of included articles were analyzed for additional papers related to the topic. The pathogenetic mechanisms underlying atherosclerosis - namely inflammation, oxidative stress and endothelial dysfunction - are in common with COPD. Moreover, they are increased in the presence of COPD, especially in patients who present airway bacterial colonization, increased rate of exacerbations and elevated levels of both airway and systemic inflammation. Conclusion: COPD is associated with an increased burden of atherosclerotic disease. Systemic inflammation and oxidative stress play key roles in this association. COPD patients with airway bacterial colonization, as compared to patients without airway colonization, generally present more frequent exacerbations and higher levels of both airway and systemic inflammation. This COPD subgroup should be considered at particularly increased risk of developing cardiovascular complications and receive more attention concerning diagnosis, treatment, prevention and research.

Original languageEnglish
Pages (from-to)915-923
Number of pages9
JournalRespiratory Medicine
Volume106
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Chronic Obstructive Pulmonary Disease
Inflammation
Atherosclerosis
Oxidative Stress
Disease Progression
Cause of Death
Chronic Disease
Morbidity
Lung
Mortality
Research

Keywords

  • Atherosclerosis
  • Bacterial colonization
  • Chronic obstructive pulmonary disease
  • Endothelial dysfunction
  • Systemic inflammation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Airway bacterial colonization : The missing link between COPD and cardiovascular events? / Fuschillo, Salvatore; Martucci, Michele; Donner, Claudio F.; Balzano, Giovanni.

In: Respiratory Medicine, Vol. 106, No. 7, 07.2012, p. 915-923.

Research output: Contribution to journalArticle

@article{92e568e355e444418325ac8cffa3e813,
title = "Airway bacterial colonization: The missing link between COPD and cardiovascular events?",
abstract = "Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and, according to the World Health Organization, its prevalence will double by 2020. COPD is a chronic inflammatory disease of the lung characterized by poorly reversible airflow limitation and, frequently, by extrapulmonary manifestations. In particular, the cardiovascular manifestations are responsible for high morbidity and mortality. Methods and results: A systematic literature search was performed of studies published in Medline until December 2010, using the key-words: COPD, bacterial colonization, COPD exacerbation, atherosclerosis, systemic inflammation, cardiovascular event and risk factors. In addition to the studies identified in the primary search, reference lists of included articles were analyzed for additional papers related to the topic. The pathogenetic mechanisms underlying atherosclerosis - namely inflammation, oxidative stress and endothelial dysfunction - are in common with COPD. Moreover, they are increased in the presence of COPD, especially in patients who present airway bacterial colonization, increased rate of exacerbations and elevated levels of both airway and systemic inflammation. Conclusion: COPD is associated with an increased burden of atherosclerotic disease. Systemic inflammation and oxidative stress play key roles in this association. COPD patients with airway bacterial colonization, as compared to patients without airway colonization, generally present more frequent exacerbations and higher levels of both airway and systemic inflammation. This COPD subgroup should be considered at particularly increased risk of developing cardiovascular complications and receive more attention concerning diagnosis, treatment, prevention and research.",
keywords = "Atherosclerosis, Bacterial colonization, Chronic obstructive pulmonary disease, Endothelial dysfunction, Systemic inflammation",
author = "Salvatore Fuschillo and Michele Martucci and Donner, {Claudio F.} and Giovanni Balzano",
year = "2012",
month = "7",
doi = "10.1016/j.rmed.2012.03.023",
language = "English",
volume = "106",
pages = "915--923",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - Airway bacterial colonization

T2 - The missing link between COPD and cardiovascular events?

AU - Fuschillo, Salvatore

AU - Martucci, Michele

AU - Donner, Claudio F.

AU - Balzano, Giovanni

PY - 2012/7

Y1 - 2012/7

N2 - Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and, according to the World Health Organization, its prevalence will double by 2020. COPD is a chronic inflammatory disease of the lung characterized by poorly reversible airflow limitation and, frequently, by extrapulmonary manifestations. In particular, the cardiovascular manifestations are responsible for high morbidity and mortality. Methods and results: A systematic literature search was performed of studies published in Medline until December 2010, using the key-words: COPD, bacterial colonization, COPD exacerbation, atherosclerosis, systemic inflammation, cardiovascular event and risk factors. In addition to the studies identified in the primary search, reference lists of included articles were analyzed for additional papers related to the topic. The pathogenetic mechanisms underlying atherosclerosis - namely inflammation, oxidative stress and endothelial dysfunction - are in common with COPD. Moreover, they are increased in the presence of COPD, especially in patients who present airway bacterial colonization, increased rate of exacerbations and elevated levels of both airway and systemic inflammation. Conclusion: COPD is associated with an increased burden of atherosclerotic disease. Systemic inflammation and oxidative stress play key roles in this association. COPD patients with airway bacterial colonization, as compared to patients without airway colonization, generally present more frequent exacerbations and higher levels of both airway and systemic inflammation. This COPD subgroup should be considered at particularly increased risk of developing cardiovascular complications and receive more attention concerning diagnosis, treatment, prevention and research.

AB - Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and, according to the World Health Organization, its prevalence will double by 2020. COPD is a chronic inflammatory disease of the lung characterized by poorly reversible airflow limitation and, frequently, by extrapulmonary manifestations. In particular, the cardiovascular manifestations are responsible for high morbidity and mortality. Methods and results: A systematic literature search was performed of studies published in Medline until December 2010, using the key-words: COPD, bacterial colonization, COPD exacerbation, atherosclerosis, systemic inflammation, cardiovascular event and risk factors. In addition to the studies identified in the primary search, reference lists of included articles were analyzed for additional papers related to the topic. The pathogenetic mechanisms underlying atherosclerosis - namely inflammation, oxidative stress and endothelial dysfunction - are in common with COPD. Moreover, they are increased in the presence of COPD, especially in patients who present airway bacterial colonization, increased rate of exacerbations and elevated levels of both airway and systemic inflammation. Conclusion: COPD is associated with an increased burden of atherosclerotic disease. Systemic inflammation and oxidative stress play key roles in this association. COPD patients with airway bacterial colonization, as compared to patients without airway colonization, generally present more frequent exacerbations and higher levels of both airway and systemic inflammation. This COPD subgroup should be considered at particularly increased risk of developing cardiovascular complications and receive more attention concerning diagnosis, treatment, prevention and research.

KW - Atherosclerosis

KW - Bacterial colonization

KW - Chronic obstructive pulmonary disease

KW - Endothelial dysfunction

KW - Systemic inflammation

UR - http://www.scopus.com/inward/record.url?scp=84861195530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861195530&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2012.03.023

DO - 10.1016/j.rmed.2012.03.023

M3 - Article

VL - 106

SP - 915

EP - 923

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 7

ER -