Airway distensibility with lung inflation after allogeneic haematopoietic stem-cell transplantation

Giovanni Barisione, Pasquale P. Pompilio, Andrea Bacigalupo, Claudia Brusasco, Alex Cioè, Raffaele L. Dellacà, Teresa Lamparelli, Alessandro Garlaschi, Riccardo Pellegrino, Vito Brusasco

Research output: Contribution to journalArticlepeer-review

Abstract

The ability to reverse induced-bronchoconstriction by deep-inhalation increases after allogeneic haematopoietic stem-cell transplantation (HSCT), despite a decreased total lung capacity (TLC). We hypothesized that this effect may be due to an increased airway distensibility with lung inflation, likely related to an increment in lung stiffness. We studied 28 subjects, 2 weeks before and 2 months after HSCT. Within-breath respiratory system conductance (Grs) at 5, 11 and 19Hz was measured by forced oscillation technique (FOT) at functional residual capacity (FRC) and TLC. Changes in conductance at 5Hz (Grs5) were related to changes in lung volume (ΔGrs5/ΔVL) to estimate airway distensibility. Grs at FRC showed a slight but significant increase at all forcing frequencies by approximately 12-16%. TLC decreased after HSCT whereas the ΔGrs5/ΔVL ratio became higher after than before HSCT and was positively correlated (R2=0.87) with lung tissue density determined by quantitative CT scanning.We conclude that airway caliber and distensibility with lung inflation are increased after HSCT. This effect seems to be related to an increase in lung stiffness and must be taken into account when interpreting lung function changes after HSCT.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume184
Issue number1
DOIs
Publication statusPublished - Oct 15 2012

Keywords

  • Airway distensibility with lung inflation
  • Allogeneic haematopoietic stem-cell transplantation
  • Bronchiolitis obliterans syndrome
  • Forced oscillation technique
  • Respiratory system conductance

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

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