Airway epithelial cell-pathogen interactions

Alessandra Bragonzi, Elena Copreni, Sophie de Bentzmann, Martina Ulrich, Massimo Conese

Research output: Contribution to journalArticlepeer-review

Abstract

Cystic fibrosis (CF) airway becomes colonized with only a limited number of bacterial pathogens. It is of paramount importance to establish in vitro and in vivo models to better understand bacterial-host interactions under CF-like conditions. In this article, in vitro methods suitable to study Pseudomonas aeruginosa (Pa) and Staphylococcus aureus (Sa) adherence to and uptake by airway epithelial cells are described. Acute and chronic respiratory infection models, which have been used in CF transgenic mice and mimic human CF lung pathology, are also taken into consideration.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalJournal of Cystic Fibrosis
Volume3
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Aug 2004

Keywords

  • Airway epithelial cells
  • Infection
  • Mouse models
  • Pseudomonas aeruginosa
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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