Abstract
Cystic fibrosis (CF) airway becomes colonized with only a limited number of bacterial pathogens. It is of paramount importance to establish in vitro and in vivo models to better understand bacterial-host interactions under CF-like conditions. In this article, in vitro methods suitable to study Pseudomonas aeruginosa (Pa) and Staphylococcus aureus (Sa) adherence to and uptake by airway epithelial cells are described. Acute and chronic respiratory infection models, which have been used in CF transgenic mice and mimic human CF lung pathology, are also taken into consideration.
Original language | English |
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Pages (from-to) | 197-201 |
Number of pages | 5 |
Journal | Journal of Cystic Fibrosis |
Volume | 3 |
Issue number | SUPPL. 2 |
DOIs | |
Publication status | Published - Aug 2004 |
Keywords
- Airway epithelial cells
- Infection
- Mouse models
- Pseudomonas aeruginosa
- Staphylococcus aureus
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine