Airway function and nasal inflammation in seasonal allergic rhinitis and asthma

G. Ciprandi, I. Cirillo, A. Vizzaccaro, M. Milanese, M. A. Tosca

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Allergic rhinitis (AR) and asthma are frequently associated and characterized by a Th2-dependent inflammation. Nasal and bronchial obstruction may be objectively measured. Objective: The aim of this study was to evaluate the relationships among upper and lower airway function and nasal inflammation in subjects with seasonal allergic rhinitis (SAR) and asthma. Methods: Twenty out-patients (12 males and eight females, mean age: 23.4+3.6 years) with SAR and asthma were evaluated during the pollen season. All of them showed a moderate-severe grade of nasal obstruction. Total symptom score, rhinomanometry, spirometry, nasal lavage, and nasal scraping were obtained in all subjects. Eosinophils were counted by conventional staining; IL-4 and IFN-γ were measured by immunoassay on fluids recovered from nasal lavage. Results: Functional parameters, i.e. nasal airflow and forced expiratory volume in 1 s (FEV1), were correlated with nasal eosinophils (R2>0. 83, P2 = 0.93, P1 (r = 0.89, P

Original languageEnglish
Pages (from-to)891-896
Number of pages6
JournalClinical and Experimental Allergy
Volume34
Issue number6
DOIs
Publication statusPublished - 2004

Keywords

  • Asthma
  • Eosinophils
  • FEV
  • Nasal airflow
  • Seasonal allergic rhinitis
  • Th1 and Th2 cytokines

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Airway function and nasal inflammation in seasonal allergic rhinitis and asthma'. Together they form a unique fingerprint.

Cite this