Airway inflammation in severe chronic obstructive pulmonary disease: Relationship with lung function and radiologic emphysema

Graziella Turato, Renzo Zuin, Massimo Miniati, Simonetta Baraldo, Federico Rea, Bianca Beghé, Simonetta Monti, Bruno Formichi, Piera Boschetto, Sergio Harari, Alberto Papi, Piero Maestrelli, Leonardo M. Fabbri, Marina Saetta

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

The lung pathology of severe chronic obstructive pulmonary disease (COPD) has been poorly investigated. We examined surgical specimens obtained from patients with severe (forced expiratory volume in 1 second [FEV 1] = 29 ± 3% predicted, n = 9) or mild/no airflow limitation (FEV 1 = 86 ± 5% predicted, n = 9) and similar smoking history. With histochemical and immunohistochemical methods we quantified the structural changes and the inflammatory cells in small airways and in muscular pulmonary arteries. As compared with smokers with mild/no COPD, smokers with severe COPD had an increased number of leukocytes in the small airways, which showed a positive correlation with the radiologic score of emphysema and with the value of residual volume, and a negative correlation with the values of FEV 1 and carbon monoxide diffusing capacity. The inflammatory process was characterized by an increase in CD8 + and CD4 + T-lymphocytes in the airway wall and by an increase in macrophages in the airway epithelium. When all smokers were considered together, the smoking history was correlated with both the airway wall and smooth muscle thickness, suggesting that smoking itself may play a role in the development of structural changes. No structural and cellular differences were observed in pulmonary arteries between smokers with severe COPD and smokers with mild/no COPD. In conclusion, in the small airways of smokers with severe COPD, there is an increased number of leukocytes, which is correlated with reduced expiratory flow, lung hyperinflation, carbon monoxide diffusion impairment, and radiologic emphysema, suggesting a role for this inflammatory response in the clinical progression of the disease.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume166
Issue number1
DOIs
Publication statusPublished - Jul 1 2002

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Emphysema
Chronic Obstructive Pulmonary Disease
Inflammation
Lung
Forced Expiratory Volume
Smoking
Carbon Monoxide
Leukocyte Count
Pulmonary Artery
History
Residual Volume
Smooth Muscle
Disease Progression
Epithelium
Macrophages
Pathology
T-Lymphocytes

Keywords

  • Airflow obstruction
  • Airway inflammation
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Airway inflammation in severe chronic obstructive pulmonary disease : Relationship with lung function and radiologic emphysema. / Turato, Graziella; Zuin, Renzo; Miniati, Massimo; Baraldo, Simonetta; Rea, Federico; Beghé, Bianca; Monti, Simonetta; Formichi, Bruno; Boschetto, Piera; Harari, Sergio; Papi, Alberto; Maestrelli, Piero; Fabbri, Leonardo M.; Saetta, Marina.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 166, No. 1, 01.07.2002, p. 105-110.

Research output: Contribution to journalArticle

Turato, G, Zuin, R, Miniati, M, Baraldo, S, Rea, F, Beghé, B, Monti, S, Formichi, B, Boschetto, P, Harari, S, Papi, A, Maestrelli, P, Fabbri, LM & Saetta, M 2002, 'Airway inflammation in severe chronic obstructive pulmonary disease: Relationship with lung function and radiologic emphysema', American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 1, pp. 105-110. https://doi.org/10.1164/rccm.2111084
Turato, Graziella ; Zuin, Renzo ; Miniati, Massimo ; Baraldo, Simonetta ; Rea, Federico ; Beghé, Bianca ; Monti, Simonetta ; Formichi, Bruno ; Boschetto, Piera ; Harari, Sergio ; Papi, Alberto ; Maestrelli, Piero ; Fabbri, Leonardo M. ; Saetta, Marina. / Airway inflammation in severe chronic obstructive pulmonary disease : Relationship with lung function and radiologic emphysema. In: American Journal of Respiratory and Critical Care Medicine. 2002 ; Vol. 166, No. 1. pp. 105-110.
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