Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia

New insights from the metabolomic approach

Silvia Carraro, Giuseppe Giordano, Paola Pirillo, Michela Maretti, Fabiano Reniero, Paola E. Cogo, Giorgio Perilongo, Matteo Stocchero, Eugenio Baraldi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R2 = 0.95 and Q2 = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy.

Original languageEnglish
Pages (from-to)234-239.e1
JournalJournal of Pediatrics
Volume166
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Bronchopulmonary Dysplasia
Metabolomics
Biomarkers
Spirometry
Discriminant Analysis
Surface-Active Agents
Mass Spectrometry
Nitric Oxide
Multivariate Analysis
Lipids
Lung

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Carraro, S., Giordano, G., Pirillo, P., Maretti, M., Reniero, F., Cogo, P. E., ... Baraldi, E. (2015). Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia: New insights from the metabolomic approach. Journal of Pediatrics, 166(2), 234-239.e1. https://doi.org/10.1016/j.jpeds.2014.08.049

Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia : New insights from the metabolomic approach. / Carraro, Silvia; Giordano, Giuseppe; Pirillo, Paola; Maretti, Michela; Reniero, Fabiano; Cogo, Paola E.; Perilongo, Giorgio; Stocchero, Matteo; Baraldi, Eugenio.

In: Journal of Pediatrics, Vol. 166, No. 2, 01.02.2015, p. 234-239.e1.

Research output: Contribution to journalArticle

Carraro, S, Giordano, G, Pirillo, P, Maretti, M, Reniero, F, Cogo, PE, Perilongo, G, Stocchero, M & Baraldi, E 2015, 'Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia: New insights from the metabolomic approach', Journal of Pediatrics, vol. 166, no. 2, pp. 234-239.e1. https://doi.org/10.1016/j.jpeds.2014.08.049
Carraro, Silvia ; Giordano, Giuseppe ; Pirillo, Paola ; Maretti, Michela ; Reniero, Fabiano ; Cogo, Paola E. ; Perilongo, Giorgio ; Stocchero, Matteo ; Baraldi, Eugenio. / Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia : New insights from the metabolomic approach. In: Journal of Pediatrics. 2015 ; Vol. 166, No. 2. pp. 234-239.e1.
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