Abstract
Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R2 = 0.95 and Q2 = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy.
| Original language | English |
|---|---|
| Pages (from-to) | 234-239.e1 |
| Journal | Journal of Pediatrics |
| Volume | 166 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2015 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Medicine(all)
Cite this
Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia : New insights from the metabolomic approach. / Carraro, Silvia; Giordano, Giuseppe; Pirillo, Paola; Maretti, Michela; Reniero, Fabiano; Cogo, Paola E.; Perilongo, Giorgio; Stocchero, Matteo; Baraldi, Eugenio.
In: Journal of Pediatrics, Vol. 166, No. 2, 01.02.2015, p. 234-239.e1.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Airway metabolic anomalies in adolescents with bronchopulmonary dysplasia
T2 - New insights from the metabolomic approach
AU - Carraro, Silvia
AU - Giordano, Giuseppe
AU - Pirillo, Paola
AU - Maretti, Michela
AU - Reniero, Fabiano
AU - Cogo, Paola E.
AU - Perilongo, Giorgio
AU - Stocchero, Matteo
AU - Baraldi, Eugenio
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R2 = 0.95 and Q2 = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy.
AB - Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R2 = 0.95 and Q2 = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy.
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UR - http://www.scopus.com/inward/citedby.url?scp=84921478375&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2014.08.049
DO - 10.1016/j.jpeds.2014.08.049
M3 - Article
VL - 166
SP - 234-239.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 2
ER -