Airway reactivity in parents of infants and young children with recurrent wheeze: A case-control study

Franca Rusconi, Franco Nizardo, Isa Cerveri, Manuela Castagneto, Franco Fanfulla,, Luigi Gagliardi, Lorenza Pugni

Research output: Contribution to journalArticlepeer-review

Abstract

Increased airway reactivity has been found in family members of school age children and adults with asthma. As the relation between recurrent wheeze in infancy and bronchial reactivity is not yet clear, it was decided to test bronchial reactivity to methacholine in both parents of 50 preschool age children with recurrent wheeze and in 200 population based controls matched for sex, age, smoking habits, and atopy. Wheezy children fulfilled the following criteria: first attack of wheezing before the age of 2 years, at least four wheezing episodes triggered by a respiratory infection, negative skin prick tests, and no symptoms related to allergy. Four parents and five controls did not undergo the methacholine challenge because their forced expiratory volume in one second was

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalArchives of Disease in Childhood
Volume73
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • Asthma
  • Bronchial reactivity
  • Methacholine challenge
  • Recurrent wheeze

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

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