AKT/NF-κB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies

Raffaella Dell'Eva, Claudia Ambrosini, Nicola Vannini, Giovanna Piaggio, Adriana Albini, Nicoletta Ferrari

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Leukemias are dependent on Akt/NF-κB activation and angiogenesis. METHODS. The antiangiogenic Akt/NF-κB inhibitor xanthohumol (XN) has in vitro activity against acute and chronic myelogenous leukemia cell lines (AML, CML) and fresh samples from patients were investigated. RESULTS. Inhibition of cell proliferation is associated with induction of apoptosis and reduced VEGF secretion. Decreased cell invasion, metalloprotease production, and adhesion to endothelial cells observed in the presence of XN could prevent in vivo life-threatening complications of leukostasis and tissue infiltration. CONCLUSIONS. As endothelial cells and hematopoietic cells are mutually correlated in their development and growth, targeting both tumor cells and endothelial cells with agents possessing cytotoxic and antiangiogenic activities may lead to synergistic antitumor effects interrupting a reciprocal stimulatory loop between leukemia and endothelial cells.

Original languageEnglish
Pages (from-to)2007-2011
Number of pages5
JournalCancer
Volume110
Issue number9
DOIs
Publication statusPublished - Nov 1 2007

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Keywords

  • Akt
  • AML
  • Angiogenesis
  • CML
  • Invasion
  • NF-κB
  • Xanthohumol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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