Albumin nanocapsules containing fenretinide: Pre-clinical evaluation of cytotoxic activity in experimental models of human non-small cell lung cancer

Sara Pignatta, Isabella Orienti, Mirella Falconi, Gabriella Teti, Chiara Arienti, Laura Medri, Michele Zanoni, Silvia Carloni, Wainer Zoli, Dino Amadori, Anna Tesei

Research output: Contribution to journalArticlepeer-review

Abstract

The present study deals with the preparation of albumin nanocapsules containing fenretinide and their evaluation in experimental models of human non-small cell lung cancer. These nanocapsules showed enhanced antitumor activity with respect to free fenretinide due to the solubilization effect of albumin on the hydrophobic drug, known to improve bioavailability. The high expression of caveolin-1 on the A549 cell surface further enhanced the antitumor activity of the nanoencapsulated fenretinide. Caveolin-1 favored albumin uptake and improved the efficacy of the fenretinide-loaded albumin nanocapsules, especially in 3-D cultures where the densely packed 3-D structures impaired drug diffusibility and severely reduced the activity of the free drug. The efficacy of the fenretinide albumin nanocapsules was further confirmed in tumor xenograft models of A549 by the significant delay in tumor progression observed with respect to control after intravenous administration of the novel formulation.

Original languageEnglish
Pages (from-to)263-273
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • 3-D cell cultures
  • Albumin
  • Fenretinide
  • In vivo experiments
  • Nanocapsules

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science
  • Medicine(all)

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