Albumin synthesis is diminished in men consuming a predominantly vegetarian diet

Giuseppe Caso, Luca Scalfi, Maurizio Marra, Alessandra Covino, Maurizio Muscaritoli, Margaret A. McNurlan, Peter J. Garlick, Franco Contaldo

Research output: Contribution to journalArticle

Abstract

Albumin synthesis was calculated in healthy male volunteers consuming diets differing in the relative contribution of protein from animal or vegetable sources. In one study (Study 1, n = 4) two isoenergetic and isonitrogenous diets were consumed for a period of 10 d each. One diet (diet A) was animal protein rich (74%), the other one (diet V) contained 67% of vegetable protein. Albumin synthesis rate was measured from L- [2H5]phenylalanine incorporation (43 mg/kg) at the end of each dietary period. Both albumin fractional synthesis rate (FSR) (5.7 ± 0.6 vs. 6.7 ± 0.8%/d, P = 0.04) and absolute synthesis rate (ASR) (123 ± 6 vs. 143 ± 8 mg · kg-1 · d-1, P = 0.05) were reduced after diet V. In a second study (Study 2, n = 8) a third dietary treatment was added (Diet VS). This was similar to diet V but supplemented with soy protein (18g/d). The results of study 2 confirmed that albumin synthesis was reduced after diet V (FSR: 5.9 ± 0.3 vs. 6.7 ± 0.5%/d, P = 0.015; ASR: 126 ± 7 vs. 146 ± 9 mg · kg-1 · d-1, P = 0.007), but it also showed that the drop could be prevented by adding supplemental protein to the predominantly vegetarian diet (Diet VS) (FSR: 6.4 ± 0.3%/d, P = 0.08; ASR: 140 ± 7 mg- kg-1 · d-1, P = 0.03). Albumin synthesis appears to be modulated by changes in the proportion of animal vs. vegetable protein occurring in the diet. The mechanism might be related to differences in digestibility and consequently in net amino acid availability between diets.

Original languageEnglish
Pages (from-to)528-533
Number of pages6
JournalJournal of Nutrition
Volume130
Issue number3
Publication statusPublished - 2000

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Vegetarian Diet
vegetarian diet
albumins
Albumins
Diet
synthesis
diet
fractional synthesis rate
Vegetable Proteins
vegetable protein
Soybean Proteins
Proteins
animal proteins
soy protein
Phenylalanine
phenylalanine
Vegetables
volunteers

Keywords

  • Albumin
  • Dietary protein
  • Humans
  • L-[H]phenylalanine
  • Protein synthesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Caso, G., Scalfi, L., Marra, M., Covino, A., Muscaritoli, M., McNurlan, M. A., ... Contaldo, F. (2000). Albumin synthesis is diminished in men consuming a predominantly vegetarian diet. Journal of Nutrition, 130(3), 528-533.

Albumin synthesis is diminished in men consuming a predominantly vegetarian diet. / Caso, Giuseppe; Scalfi, Luca; Marra, Maurizio; Covino, Alessandra; Muscaritoli, Maurizio; McNurlan, Margaret A.; Garlick, Peter J.; Contaldo, Franco.

In: Journal of Nutrition, Vol. 130, No. 3, 2000, p. 528-533.

Research output: Contribution to journalArticle

Caso, G, Scalfi, L, Marra, M, Covino, A, Muscaritoli, M, McNurlan, MA, Garlick, PJ & Contaldo, F 2000, 'Albumin synthesis is diminished in men consuming a predominantly vegetarian diet', Journal of Nutrition, vol. 130, no. 3, pp. 528-533.
Caso G, Scalfi L, Marra M, Covino A, Muscaritoli M, McNurlan MA et al. Albumin synthesis is diminished in men consuming a predominantly vegetarian diet. Journal of Nutrition. 2000;130(3):528-533.
Caso, Giuseppe ; Scalfi, Luca ; Marra, Maurizio ; Covino, Alessandra ; Muscaritoli, Maurizio ; McNurlan, Margaret A. ; Garlick, Peter J. ; Contaldo, Franco. / Albumin synthesis is diminished in men consuming a predominantly vegetarian diet. In: Journal of Nutrition. 2000 ; Vol. 130, No. 3. pp. 528-533.
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abstract = "Albumin synthesis was calculated in healthy male volunteers consuming diets differing in the relative contribution of protein from animal or vegetable sources. In one study (Study 1, n = 4) two isoenergetic and isonitrogenous diets were consumed for a period of 10 d each. One diet (diet A) was animal protein rich (74{\%}), the other one (diet V) contained 67{\%} of vegetable protein. Albumin synthesis rate was measured from L- [2H5]phenylalanine incorporation (43 mg/kg) at the end of each dietary period. Both albumin fractional synthesis rate (FSR) (5.7 ± 0.6 vs. 6.7 ± 0.8{\%}/d, P = 0.04) and absolute synthesis rate (ASR) (123 ± 6 vs. 143 ± 8 mg · kg-1 · d-1, P = 0.05) were reduced after diet V. In a second study (Study 2, n = 8) a third dietary treatment was added (Diet VS). This was similar to diet V but supplemented with soy protein (18g/d). The results of study 2 confirmed that albumin synthesis was reduced after diet V (FSR: 5.9 ± 0.3 vs. 6.7 ± 0.5{\%}/d, P = 0.015; ASR: 126 ± 7 vs. 146 ± 9 mg · kg-1 · d-1, P = 0.007), but it also showed that the drop could be prevented by adding supplemental protein to the predominantly vegetarian diet (Diet VS) (FSR: 6.4 ± 0.3{\%}/d, P = 0.08; ASR: 140 ± 7 mg- kg-1 · d-1, P = 0.03). Albumin synthesis appears to be modulated by changes in the proportion of animal vs. vegetable protein occurring in the diet. The mechanism might be related to differences in digestibility and consequently in net amino acid availability between diets.",
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