Albuminuria and blood pressure, independent targets for cardioprotective therapy in patients with diabetes and nephropathy: A post hoc analysis of the combined RENAAL and IDNT trials

Frank A. Holtkamp, Dick De Zeeuw, Pieter A. De Graeff, Gozewijn D. Laverman, Tom Berl, Giuseppe Remuzzi, David Packham, Julia B. Lewis, Hans Henrik Parving, Hiddo J. Lambers Heerspink

Research output: Contribution to journalArticlepeer-review

Abstract

AimsThe long-term cardioprotective effect of angiotensin receptor blockers (ARBs) is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. Since the individual blood pressure and albuminuria response to an ARB varies between and within an individual, we tested whether the variability and discordance in systolic blood pressure (SBP) and albuminuria response to ARB therapy are associated with its long-term effect on cardiovascular outcomes.Methods and resultsThe combined data of the RENAAL and IDNT trials were used. We first investigated the extent of variability and discordance in SBP and albuminuria response (baseline to 6 months). Subsequently, we assessed the combined impact of residual Month 6 SBP and albuminuria level with cardiovascular outcome. In ARB-treated patients, 421 patients (34.5) either had a reduction in SBP but no reduction in albuminuria, or vice versa, indicating substantial discordance in response in these parameters. The initial reduction in SBP and albuminuria independently correlated with cardiovascular protection: HR per 5 mmHg SBP reduction 0.97 (95 CI 0.940.99) and HR per decrement log albuminuria 0.87 (95 CI 0.760.99). Across all SBP categories at Month 6, a progressively lower cardiovascular risk was observed with a lower albuminuria level. This was particularly evident in patients who reached the guideline recommended SBP target of ≤130 mmHg.ConclusionThe SBP and albuminuria response to ARB therapy is variable and discordant. Therapies intervening in the reninangiotensinaldosterone system with the aim of improving cardiovascular outcomes may therefore require a dual approach targeting both blood pressure and albuminuria.

Original languageEnglish
Pages (from-to)1493-1499
Number of pages7
JournalEuropean Heart Journal
Volume32
Issue number12
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Albuminuria
  • Angiotensin receptor blocker
  • Blood pressure
  • Cardiovascular disease
  • Diabetic Nephropathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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