Alcohol addiction - the safety of available approved treatment options

Mariangela Antonelli, Anna Ferrulli, Luisa Sestito, Gabriele A. Vassallo, Claudia Tarli, Carolina Mosoni, Maria M. Rando, Antonio Mirijello, Antonio Gasbarrini, Giovanni Addolorato

Research output: Contribution to journalReview article

Abstract

Introduction: Alcohol Use Disorders (AUD) is a leading cause of mortality and morbidity worldwide. At present disulfiram, naltrexone and acamprosate are approved for the treatment of AUD in U.S. and Europe. Nalmefene is approved in Europe and sodium oxybate is approved in Italy and Austria only. Baclofen received a ‘temporary recommendation for use’ in France. Areas covered: The safety of the above mentioned medications on liver, digestive system, kidney function, nervous system, pregnancy and lactation and their possible side effects are described and discussed. Expert opinion: Mechanism of action and metabolism of these drugs as well as patients’ clinical characteristics can affect the safety of treatment. All approved medications are valid tools for the treatment of AUD in patients without advanced liver disease. For some drugs, attention should be paid to patients with renal failure and medications may be used with caution, adjusting the dosage according to kidney function. In patients with AUD and advanced liver disease, at present only baclofen has been formally tested in randomized controlled trials showing its safety in this population.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalExpert Opinion on Drug Safety
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

Keywords

  • Alcohol
  • alcohol dependence
  • AUD
  • craving
  • safety

ASJC Scopus subject areas

  • Pharmacology (medical)

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  • Cite this

    Antonelli, M., Ferrulli, A., Sestito, L., Vassallo, G. A., Tarli, C., Mosoni, C., Rando, M. M., Mirijello, A., Gasbarrini, A., & Addolorato, G. (2018). Alcohol addiction - the safety of available approved treatment options. Expert Opinion on Drug Safety, 17(2), 169-177. https://doi.org/10.1080/14740338.2018.1404025