Alcohol and endometrial cancer risk: A case-control study and a meta-analysis

Federica Turati, Silvano Gallus, Alessandra Tavani, Irene Tramacere, Jerry Polesel, Renato Talamini, Maurizio Montella, Lorenza Scotti, Silvia Franceshi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


To evaluate the association between alcohol consumption and endometrial cancer risk, we analyzed data from a hospital-based case-control study, conducted in Italy between 1992 and 2006, on 454 endometrial cancer cases and 908 controls, and performed a meta-analysis updated to October 2009. Compared to never alcohol drinkers, the odds ratio was 1.03 (95% confidence interval, CI, 0.76-1.41) for ≥ 7, 1.27 (95% CI 0.86-1.87) for 8-14, and 1.19 (95% CI 0.80-1.77) for ≥ 15 drinks/week, with no trend in risk. No association emerged for wine, beer, and spirit consumption analyzed separately. The meta-analysis included 20 case-control and seven cohort studies, for a total of 13,120 cases. Compared to non/low drinkers, the pooled relative risks for drinkers were 0.90 (95% CI 0.80-1.01) for case-control studies, 1.01 (95% CI 0.90-1.14) for cohort studies, and 0.95 (95% CI 0.88-1.03) overall, with no heterogeneity between study design (p = 0.156). The overall estimate for heavy versus non/low drinkers was 1.12 (95% CI 0.87-1.45). The results were consistent according to selected study characteristics, including geographic area, definition of alcohol drinkers, and type of controls in case-control studies. Our findings provide evidence that alcohol drinking is not associated with endometrial cancer risk, although a weak positive association for very high drinkers cannot be excluded.

Original languageEnglish
Pages (from-to)1285-1296
Number of pages12
JournalCancer Causes and Control
Issue number8
Publication statusPublished - Aug 2010


  • Alcohol
  • Case-control study
  • Endometrial cancer risk
  • Meta-analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)


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