Alcohol and liver cancer: A systematic review and meta-analysis of prospective studies

F. Turati, C. Galeone, M. Rota, Claudio Pelucchi, E. Negri, V. Bagnardi, G. Corrao, P. Boffetta, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

Despite several studies support a positive association between heavy alcohol consumption and liver cancer risk, a consistent dose-risk relationship has not yet been established. We carried out a systematic review and a meta-analysis of the association between alcohol intake and liver cancer occurrence, following the Meta-analysis Of Observational Studies in Epidemiology guidelines. We searched for cohort and nested case-control studies on the general population published before April 2013, using PubMed and EMBASE. Summary meta-analytic relative risks (RRs) were estimated using random-effect models. We included 16 articles (19 cohorts) for a total of 4445 incident cases and 5550 deaths from liver cancer. Compared with non-drinking, the pooled RRs were 0.91 (95% confidence interval, CI, 0.81-1.02) for moderate drinking (

Original languageEnglish
Article numbermdu020
Pages (from-to)1526-1535
Number of pages10
JournalAnnals of Oncology
Volume25
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Alcohol
  • Epidemiology
  • Liver cancer
  • Meta-analysis
  • Risk factors
  • Systematic review

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

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    Turati, F., Galeone, C., Rota, M., Pelucchi, C., Negri, E., Bagnardi, V., Corrao, G., Boffetta, P., & La Vecchia, C. (2014). Alcohol and liver cancer: A systematic review and meta-analysis of prospective studies. Annals of Oncology, 25(8), 1526-1535. [mdu020]. https://doi.org/10.1093/annonc/mdu020