Alcohol and wine in relation to cancer and other diseases

Attilio Giacosa, Anne F. Adam-Blondon, Sara Baer-Sinnott, Roberto Barale, Luigi Bavaresco, Gabriele Di Gaspero, Laura Dugo, Robert Curtis Ellison, Vincenzo Gerbi, Dun Gifford, Jaak Janssens, Carlo La Vecchia, Eva Negri, Mario Pezzotti, Leonardo Santi, Luca Santi, Mariangela Rondanelli

Research output: Contribution to journalArticlepeer-review


Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalEuropean Journal of Cancer Prevention
Issue number1
Publication statusPublished - Jan 2012


  • Alcohol
  • Cancer
  • Genomics
  • Polyphenols
  • Resveratrol
  • Wine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health


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