Abstract
Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic.
| Original language | English |
|---|---|
| Pages (from-to) | 103-108 |
| Number of pages | 6 |
| Journal | European Journal of Cancer Prevention |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2012 |
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Keywords
- Alcohol
- Cancer
- Genomics
- Polyphenols
- Resveratrol
- Wine
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Epidemiology
- Public Health, Environmental and Occupational Health
Cite this
Alcohol and wine in relation to cancer and other diseases. / Giacosa, Attilio; Adam-Blondon, Anne F.; Baer-Sinnott, Sara; Barale, Roberto; Bavaresco, Luigi; Di Gaspero, Gabriele; Dugo, Laura; Curtis Ellison, Robert; Gerbi, Vincenzo; Gifford, Dun; Janssens, Jaak; La Vecchia, Carlo; Negri, Eva; Pezzotti, Mario; Santi, Leonardo; Santi, Luca; Rondanelli, Mariangela.
In: European Journal of Cancer Prevention, Vol. 21, No. 1, 01.2012, p. 103-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol and wine in relation to cancer and other diseases
AU - Giacosa, Attilio
AU - Adam-Blondon, Anne F.
AU - Baer-Sinnott, Sara
AU - Barale, Roberto
AU - Bavaresco, Luigi
AU - Di Gaspero, Gabriele
AU - Dugo, Laura
AU - Curtis Ellison, Robert
AU - Gerbi, Vincenzo
AU - Gifford, Dun
AU - Janssens, Jaak
AU - La Vecchia, Carlo
AU - Negri, Eva
AU - Pezzotti, Mario
AU - Santi, Leonardo
AU - Santi, Luca
AU - Rondanelli, Mariangela
PY - 2012/1
Y1 - 2012/1
N2 - Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic.
AB - Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic.
KW - Alcohol
KW - Cancer
KW - Genomics
KW - Polyphenols
KW - Resveratrol
KW - Wine
UR - http://www.scopus.com/inward/record.url?scp=82555169614&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82555169614&partnerID=8YFLogxK
U2 - 10.1097/CEJ.0b013e32834761d3
DO - 10.1097/CEJ.0b013e32834761d3
M3 - Article
C2 - 22001915
AN - SCOPUS:82555169614
VL - 21
SP - 103
EP - 108
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 1
ER -