Consumo dl bevande alcoliche e rischio dl tumori epiteliali nella coorte Epic-Italia

Translated title of the contribution: Alcohol consumption and epithelial cancer risk in the Epic-Italy cohort

Calogero Saieva, Saverio Caini, Marco Ceroti, Francesco Fasanelli, Fulvio Ricceri, Claudia Agnoli, Sara Grioni, Amalia Mattiello, Maria Santucci De Magistris, Rosario Tumino, Caierina Martorana, Giovanna Masala

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To evaluate the association between baseline and lifetime alcohol consumption and the risk of epithelial cancer (all types) in the Italian cohort of the European Prospective Investigation into Cancer and nutrition (EPIC) study. DESIGN: prospective study carried out in a large Italian population. SETTING AND PARTICIPANTS: detailed information on the consumption of alcoholic beverages at baseline and over lifetime collected at enrolment into the EPIC study (1993-1998) by standardised questionnaires for 44,477 healthy adults. MAIN OUTCOMES MEASURES: 2,640 incident epithelial cancers identified during a mean follow-up of 11.4 years. Multivariate Cox proportional hazard models adjusted for several potential confounders were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI). RESULTS: lifetime alcohol consumption (p for trend =0.005) was associated with epithelial cancer risk in the whole cohort. This effect was more evident in women (p =0.049) and in current smokers (p =0.012). Alcohol consumption at baseline was associated with the epithelial cancer risk in women (p for trend =0.01) and current smokers (p for trend =0.02). A significant interaction between alcohol consumption and smoke duration (p =0.015 for baseline; p =0.006 for lifetime) was identified. CONCLUSIONS: in this large Italian population, alcohol consumption, particularly lifetime, is a significant risk factor for the development of epithelial cancers. This effect appears to be modulated by smoking habits.

Translated title of the contributionAlcohol consumption and epithelial cancer risk in the Epic-Italy cohort
Original languageItalian
Pages (from-to)345-349
Number of pages5
JournalEpidemiologia e prevenzione
Volume39
Issue number5-6
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

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    Saieva, C., Caini, S., Ceroti, M., Fasanelli, F., Ricceri, F., Agnoli, C., Grioni, S., Mattiello, A., De Magistris, M. S., Tumino, R., Martorana, C., & Masala, G. (2015). Consumo dl bevande alcoliche e rischio dl tumori epiteliali nella coorte Epic-Italia. Epidemiologia e prevenzione, 39(5-6), 345-349.