Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Eric J. Duell, Noémie Travier, Leila Lujan-Barroso, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Sophie Morois, Domenico Palli, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, J. Ramón Quirós, Emilio Sánchez-Cantalejo, Carmen Navarro, Aurelio Barricarte Gurrea, Miren Dorronsoro, Kay Tee Khaw, Naomi E. Allen, Timothy J. Key, H. Bas Bueno-De-MesquitaMartine M. Ros, Mattijs E. Numans, Petra H M Peeters, Antonia Trichopoulou, Androniki Naska, Vardis Dilis, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Sara Regner, Björn Lindkvist, Ingegerd Johansson, Göran Hallmans, Kim Overvad, Rikke Egeberg, Anne Tjønneland, Eiliv Lund, Elisabete Weiderpass, Tonje Braaten, Isabelle Romieu, Pietro Ferrari, Mazda Jenab, Roger Stenling, Dagfinn Aune, Teresa Norat, Elio Riboli, Carlos A. González

Research output: Contribution to journalArticle

Abstract

Background: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. Objective: We evaluated the association between alcohol consumption and GC risk. Design: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. Results: Heavy (compared with very light) alcohol consumption (≥60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (

Original languageEnglish
Pages (from-to)1266-1275
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number5
DOIs
Publication statusPublished - Nov 1 2011

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Alcohol Drinking
Stomach Neoplasms
Neoplasms
Cardia
Helicobacter pylori
Epidemiologic Studies
Cause of Death
Stomach
Adenocarcinoma
Ethanol
Smoking
Light

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Duell, E. J., Travier, N., Lujan-Barroso, L., Clavel-Chapelon, F., Boutron-Ruault, M. C., Morois, S., ... González, C. A. (2011). Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. American Journal of Clinical Nutrition, 94(5), 1266-1275. https://doi.org/10.3945/ajcn.111.012351

Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. / Duell, Eric J.; Travier, Noémie; Lujan-Barroso, Leila; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Morois, Sophie; Palli, Domenico; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Quirós, J. Ramón; Sánchez-Cantalejo, Emilio; Navarro, Carmen; Gurrea, Aurelio Barricarte; Dorronsoro, Miren; Khaw, Kay Tee; Allen, Naomi E.; Key, Timothy J.; Bueno-De-Mesquita, H. Bas; Ros, Martine M.; Numans, Mattijs E.; Peeters, Petra H M; Trichopoulou, Antonia; Naska, Androniki; Dilis, Vardis; Teucher, Birgit; Kaaks, Rudolf; Boeing, Heiner; Schütze, Madlen; Regner, Sara; Lindkvist, Björn; Johansson, Ingegerd; Hallmans, Göran; Overvad, Kim; Egeberg, Rikke; Tjønneland, Anne; Lund, Eiliv; Weiderpass, Elisabete; Braaten, Tonje; Romieu, Isabelle; Ferrari, Pietro; Jenab, Mazda; Stenling, Roger; Aune, Dagfinn; Norat, Teresa; Riboli, Elio; González, Carlos A.

In: American Journal of Clinical Nutrition, Vol. 94, No. 5, 01.11.2011, p. 1266-1275.

Research output: Contribution to journalArticle

Duell, EJ, Travier, N, Lujan-Barroso, L, Clavel-Chapelon, F, Boutron-Ruault, MC, Morois, S, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Quirós, JR, Sánchez-Cantalejo, E, Navarro, C, Gurrea, AB, Dorronsoro, M, Khaw, KT, Allen, NE, Key, TJ, Bueno-De-Mesquita, HB, Ros, MM, Numans, ME, Peeters, PHM, Trichopoulou, A, Naska, A, Dilis, V, Teucher, B, Kaaks, R, Boeing, H, Schütze, M, Regner, S, Lindkvist, B, Johansson, I, Hallmans, G, Overvad, K, Egeberg, R, Tjønneland, A, Lund, E, Weiderpass, E, Braaten, T, Romieu, I, Ferrari, P, Jenab, M, Stenling, R, Aune, D, Norat, T, Riboli, E & González, CA 2011, 'Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort', American Journal of Clinical Nutrition, vol. 94, no. 5, pp. 1266-1275. https://doi.org/10.3945/ajcn.111.012351
Duell, Eric J. ; Travier, Noémie ; Lujan-Barroso, Leila ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Morois, Sophie ; Palli, Domenico ; Krogh, Vittorio ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Quirós, J. Ramón ; Sánchez-Cantalejo, Emilio ; Navarro, Carmen ; Gurrea, Aurelio Barricarte ; Dorronsoro, Miren ; Khaw, Kay Tee ; Allen, Naomi E. ; Key, Timothy J. ; Bueno-De-Mesquita, H. Bas ; Ros, Martine M. ; Numans, Mattijs E. ; Peeters, Petra H M ; Trichopoulou, Antonia ; Naska, Androniki ; Dilis, Vardis ; Teucher, Birgit ; Kaaks, Rudolf ; Boeing, Heiner ; Schütze, Madlen ; Regner, Sara ; Lindkvist, Björn ; Johansson, Ingegerd ; Hallmans, Göran ; Overvad, Kim ; Egeberg, Rikke ; Tjønneland, Anne ; Lund, Eiliv ; Weiderpass, Elisabete ; Braaten, Tonje ; Romieu, Isabelle ; Ferrari, Pietro ; Jenab, Mazda ; Stenling, Roger ; Aune, Dagfinn ; Norat, Teresa ; Riboli, Elio ; González, Carlos A. / Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In: American Journal of Clinical Nutrition. 2011 ; Vol. 94, No. 5. pp. 1266-1275.
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AU - Duell, Eric J.

AU - Travier, Noémie

AU - Lujan-Barroso, Leila

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Morois, Sophie

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Quirós, J. Ramón

AU - Sánchez-Cantalejo, Emilio

AU - Navarro, Carmen

AU - Gurrea, Aurelio Barricarte

AU - Dorronsoro, Miren

AU - Khaw, Kay Tee

AU - Allen, Naomi E.

AU - Key, Timothy J.

AU - Bueno-De-Mesquita, H. Bas

AU - Ros, Martine M.

AU - Numans, Mattijs E.

AU - Peeters, Petra H M

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Dilis, Vardis

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Regner, Sara

AU - Lindkvist, Björn

AU - Johansson, Ingegerd

AU - Hallmans, Göran

AU - Overvad, Kim

AU - Egeberg, Rikke

AU - Tjønneland, Anne

AU - Lund, Eiliv

AU - Weiderpass, Elisabete

AU - Braaten, Tonje

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Stenling, Roger

AU - Aune, Dagfinn

AU - Norat, Teresa

AU - Riboli, Elio

AU - González, Carlos A.

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