Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Darren R. Brenner, Gord Fehringer, Zuo Feng Zhang, Yuan Chin Amy Lee, Travis Meyers, Keitaro Matsuo, Hidemi Ito, Paolo Vineis, Isabelle Stucker, Paolo Boffetta, Paul Brennan, David C. Christiani, Nancy Diao, Yun Chul Hong, Maria T. Landi, Hal Morgenstern, Ann G. Schwartz, Gad Rennert, Walid Saliba, John R. McLaughlinCurtis C. Harris, Irene Orlow, Juan M. Barros Dios, Alberto Ruano Raviña, Jack Siemiatycki, Anita Koushik, Michele Cote, Philip Lazarus, Guillermo Fernandez-Tardon, Adonina Tardon, Loïc Le Marchand, Hermann Brenner, Kai Uwe Saum, Eric J. Duell, Angeline S. Andrew, Dario Consonni, Ann Olsson, Rayjean J. Hung, Kurt Straif

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalCancer Epidemiology
Volume58
DOIs
Publication statusPublished - Feb 1 2019

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Alcohol Drinking
Lung Neoplasms
Squamous Cell Carcinoma
Alcoholic Beverages
Odds Ratio
Confidence Intervals
Beverages
Drinking
Case-Control Studies
Cohort Studies
Ethanol
Alcohols

Keywords

  • Alcohol
  • Lung cancer
  • Pooled analysis

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Alcohol consumption and lung cancer risk : A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. / Brenner, Darren R.; Fehringer, Gord; Zhang, Zuo Feng; Lee, Yuan Chin Amy; Meyers, Travis; Matsuo, Keitaro; Ito, Hidemi; Vineis, Paolo; Stucker, Isabelle; Boffetta, Paolo; Brennan, Paul; Christiani, David C.; Diao, Nancy; Hong, Yun Chul; Landi, Maria T.; Morgenstern, Hal; Schwartz, Ann G.; Rennert, Gad; Saliba, Walid; McLaughlin, John R.; Harris, Curtis C.; Orlow, Irene; Barros Dios, Juan M.; Ruano Raviña, Alberto; Siemiatycki, Jack; Koushik, Anita; Cote, Michele; Lazarus, Philip; Fernandez-Tardon, Guillermo; Tardon, Adonina; Le Marchand, Loïc; Brenner, Hermann; Saum, Kai Uwe; Duell, Eric J.; Andrew, Angeline S.; Consonni, Dario; Olsson, Ann; Hung, Rayjean J.; Straif, Kurt.

In: Cancer Epidemiology, Vol. 58, 01.02.2019, p. 25-32.

Research output: Contribution to journalArticle

Brenner, DR, Fehringer, G, Zhang, ZF, Lee, YCA, Meyers, T, Matsuo, K, Ito, H, Vineis, P, Stucker, I, Boffetta, P, Brennan, P, Christiani, DC, Diao, N, Hong, YC, Landi, MT, Morgenstern, H, Schwartz, AG, Rennert, G, Saliba, W, McLaughlin, JR, Harris, CC, Orlow, I, Barros Dios, JM, Ruano Raviña, A, Siemiatycki, J, Koushik, A, Cote, M, Lazarus, P, Fernandez-Tardon, G, Tardon, A, Le Marchand, L, Brenner, H, Saum, KU, Duell, EJ, Andrew, AS, Consonni, D, Olsson, A, Hung, RJ & Straif, K 2019, 'Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study', Cancer Epidemiology, vol. 58, pp. 25-32. https://doi.org/10.1016/j.canep.2018.10.006
Brenner, Darren R. ; Fehringer, Gord ; Zhang, Zuo Feng ; Lee, Yuan Chin Amy ; Meyers, Travis ; Matsuo, Keitaro ; Ito, Hidemi ; Vineis, Paolo ; Stucker, Isabelle ; Boffetta, Paolo ; Brennan, Paul ; Christiani, David C. ; Diao, Nancy ; Hong, Yun Chul ; Landi, Maria T. ; Morgenstern, Hal ; Schwartz, Ann G. ; Rennert, Gad ; Saliba, Walid ; McLaughlin, John R. ; Harris, Curtis C. ; Orlow, Irene ; Barros Dios, Juan M. ; Ruano Raviña, Alberto ; Siemiatycki, Jack ; Koushik, Anita ; Cote, Michele ; Lazarus, Philip ; Fernandez-Tardon, Guillermo ; Tardon, Adonina ; Le Marchand, Loïc ; Brenner, Hermann ; Saum, Kai Uwe ; Duell, Eric J. ; Andrew, Angeline S. ; Consonni, Dario ; Olsson, Ann ; Hung, Rayjean J. ; Straif, Kurt. / Alcohol consumption and lung cancer risk : A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. In: Cancer Epidemiology. 2019 ; Vol. 58. pp. 25-32.
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abstract = "Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95{\%} confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95{\%} CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95{\%} CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.",
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T2 - A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

AU - Brenner, Darren R.

AU - Fehringer, Gord

AU - Zhang, Zuo Feng

AU - Lee, Yuan Chin Amy

AU - Meyers, Travis

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Vineis, Paolo

AU - Stucker, Isabelle

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Christiani, David C.

AU - Diao, Nancy

AU - Hong, Yun Chul

AU - Landi, Maria T.

AU - Morgenstern, Hal

AU - Schwartz, Ann G.

AU - Rennert, Gad

AU - Saliba, Walid

AU - McLaughlin, John R.

AU - Harris, Curtis C.

AU - Orlow, Irene

AU - Barros Dios, Juan M.

AU - Ruano Raviña, Alberto

AU - Siemiatycki, Jack

AU - Koushik, Anita

AU - Cote, Michele

AU - Lazarus, Philip

AU - Fernandez-Tardon, Guillermo

AU - Tardon, Adonina

AU - Le Marchand, Loïc

AU - Brenner, Hermann

AU - Saum, Kai Uwe

AU - Duell, Eric J.

AU - Andrew, Angeline S.

AU - Consonni, Dario

AU - Olsson, Ann

AU - Hung, Rayjean J.

AU - Straif, Kurt

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

AB - Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

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KW - Lung cancer

KW - Pooled analysis

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