Alcohol consumption and prostate cancer risk: A meta-analysis of the dose-risk relation

Matteo Rota, Lorenza Scotti, Federica Turati, Irene Tramacere, Farhad Islami, Rino Bellocco, Eva Negri, Giovanni Corrao, Paolo Boffetta, Carlo La Vecchia, Vincenzo Bagnardi

Research output: Contribution to journalArticlepeer-review

Abstract

Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤1 drink/day), moderate (>1 to

Original languageEnglish
Pages (from-to)350-359
Number of pages10
JournalEuropean Journal of Cancer Prevention
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2012

Keywords

  • alcohol drinking
  • dose-risk relation
  • meta-analysis
  • prostate neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

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