Alcohol consumption and renal cell cancer risk in two Italian case-control studies

C. Pelucchi, C. Galeone, M. Montella, J. Polesel, A. Crispo, R. Talamini, E. Negri, V. Ramazzotti, M. Grimaldi, S. Franceschi, C. La Vecchia

Research output: Contribution to journalArticle

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Abstract

Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.

Original languageEnglish
Pages (from-to)1003-1008
Number of pages6
JournalAnnals of Oncology
Volume19
Issue number5
DOIs
Publication statusPublished - May 2008

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Renal Cell Carcinoma
Alcohol Drinking
Case-Control Studies
Confidence Intervals
Odds Ratio
Alcoholic Beverages
Wine
Body Mass Index
Smoking
Alcohols

Keywords

  • Alcohol drinking
  • Alcoholic beverages
  • Case-control studies
  • Renal cell carcinoma
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Alcohol consumption and renal cell cancer risk in two Italian case-control studies. / Pelucchi, C.; Galeone, C.; Montella, M.; Polesel, J.; Crispo, A.; Talamini, R.; Negri, E.; Ramazzotti, V.; Grimaldi, M.; Franceschi, S.; La Vecchia, C.

In: Annals of Oncology, Vol. 19, No. 5, 05.2008, p. 1003-1008.

Research output: Contribution to journalArticle

Pelucchi, C, Galeone, C, Montella, M, Polesel, J, Crispo, A, Talamini, R, Negri, E, Ramazzotti, V, Grimaldi, M, Franceschi, S & La Vecchia, C 2008, 'Alcohol consumption and renal cell cancer risk in two Italian case-control studies', Annals of Oncology, vol. 19, no. 5, pp. 1003-1008. https://doi.org/10.1093/annonc/mdm590
Pelucchi, C. ; Galeone, C. ; Montella, M. ; Polesel, J. ; Crispo, A. ; Talamini, R. ; Negri, E. ; Ramazzotti, V. ; Grimaldi, M. ; Franceschi, S. ; La Vecchia, C. / Alcohol consumption and renal cell cancer risk in two Italian case-control studies. In: Annals of Oncology. 2008 ; Vol. 19, No. 5. pp. 1003-1008.
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abstract = "Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95{\%} confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95{\%} CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95{\%} CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95{\%} CI 0.71-1.02) for wine, 0.84 (95{\%} CI 0.68-1.03) for beer and 0.86 (95{\%} CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.",
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T1 - Alcohol consumption and renal cell cancer risk in two Italian case-control studies

AU - Pelucchi, C.

AU - Galeone, C.

AU - Montella, M.

AU - Polesel, J.

AU - Crispo, A.

AU - Talamini, R.

AU - Negri, E.

AU - Ramazzotti, V.

AU - Grimaldi, M.

AU - Franceschi, S.

AU - La Vecchia, C.

PY - 2008/5

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N2 - Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.

AB - Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.

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