Abstract
Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.
| Original language | English |
|---|---|
| Pages (from-to) | 1003-1008 |
| Number of pages | 6 |
| Journal | Annals of Oncology |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- Alcohol drinking
- Alcoholic beverages
- Case-control studies
- Renal cell carcinoma
- Risk factors
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Alcohol consumption and renal cell cancer risk in two Italian case-control studies. / Pelucchi, C.; Galeone, C.; Montella, M.; Polesel, J.; Crispo, A.; Talamini, R.; Negri, E.; Ramazzotti, V.; Grimaldi, M.; Franceschi, S.; La Vecchia, C.
In: Annals of Oncology, Vol. 19, No. 5, 05.2008, p. 1003-1008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol consumption and renal cell cancer risk in two Italian case-control studies
AU - Pelucchi, C.
AU - Galeone, C.
AU - Montella, M.
AU - Polesel, J.
AU - Crispo, A.
AU - Talamini, R.
AU - Negri, E.
AU - Ramazzotti, V.
AU - Grimaldi, M.
AU - Franceschi, S.
AU - La Vecchia, C.
PY - 2008/5
Y1 - 2008/5
N2 - Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.
AB - Background: There is some evidence that alcohol consumption is inversely associated with renal cell cancer (RCC), but the issue is still unclear. Patients and methods: We investigated the relation using data from two Italian multicentric case-control studies conducted from 1985 to 2004, including a total of 1115 incident, histologically confirmed cases and 2582 controls hospitalised with acute, non-neoplastic conditions. Results: Compared with non-drinkers, the multivariate odds ratios (ORs) of RCC were 0.87 [95% confidence interval (CI) 0.73-1.04] for ≤4 drinks per day, 0.76 (95% CI 0.59-0.99) for >4 to ≤8 drinks per day and 0.70 (95% CI 0.50-0.97) for >8 drinks per day of alcoholic beverages, with a significant inverse trend in risk (P value = 0.01). The ORs were 0.85 (95% CI 0.71-1.02) for wine, 0.84 (95% CI 0.68-1.03) for beer and 0.86 (95% CI 0.70-1.05) for spirits consumption, as compared with abstainers. No trend in risk of RCC emerged with duration (P value = 0.94) and age at starting alcohol consumption (P value = 0.81). Results were consistent in men and women, as well as in strata of age, smoking and body mass index. Conclusions: This pooled analysis found an inverse association between alcohol drinking and RCC. Risks continued to decrease even above eight drinks per day (i.e. >100 g/day) of alcohol intake, with no apparent levelling in risk.
KW - Alcohol drinking
KW - Alcoholic beverages
KW - Case-control studies
KW - Renal cell carcinoma
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=43049103828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049103828&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdm590
DO - 10.1093/annonc/mdm590
M3 - Article
C2 - 18187482
AN - SCOPUS:43049103828
VL - 19
SP - 1003
EP - 1008
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 5
ER -