Abstract
A population-based case-control study of 649 leukemia cases and 1771 controls carried out in 11 Italian areas, offered the opportunity to evaluate the relationship between alcohol consumption and leukemia risk. For all leukemias, acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL), we found a non-significantly inverse association for moderate levels of total alcohol and wine intake, but increased risks at high levels, with, in most cases, significant trend effects (odd ratios (OR) for all leukemias in the lowest quartile of total alcohol consumption [0.1-9.0 g/day of ethanol] versus never-drinker = 0.73; 95% confidence intervals (95% CI) = 0.51-1.03; OR in the highest quartile [> 31.7 g/day] = 1.15; 95% CI = 0.82-1.63; p of the linear trend test = 0.007). For chronic myeloid leukemia (CML), we found a non-significantly positive association for all levels of total alcohol and wine intake, and a significant positive linear trend effect (p = 0.03) for wine intake (OR for 0.1-9.0 g/day of ethanol intake from wine = 1.34; 95% CI = 0.61-2.94; OR in the highest quartile of wine intake [> 27.7 g/day] = 2.13; 95% CI = 1.01-4.50). No consistent dose-response was detected analysing duration of alcohol consumption for any leukemia subtypes. In conclusion, even though our study did not show a clear association between alcohol intake and leukemia risk, some of the patterns of the risk estimates (a possible J-shaped dose-response curve between alcohol intake and ALL, AML, and CLL risks, and the positive association between alcohol and CML), may be suggestive.
| Original language | English |
|---|---|
| Pages (from-to) | 379-386 |
| Number of pages | 8 |
| Journal | Leukemia Research |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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Keywords
- Adult leukemia
- Alcohol
- Case-control study
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Alcohol consumption and risk of leukemia : A multicenter case-control study. / Gorini, Giuseppe; Stagnaro, Emanuele; Fontana, Vincenzo; Miligi, Lucia; Ramazzotti, Valerio; Nanni, Oriana; Rodella, Stefania; Tumino, Rosario; Crosignani, Paolo; Vindigni, Carla; Fontana, Arabella; Vineis, Paolo; Costantini, Adele Seniori.
In: Leukemia Research, Vol. 31, No. 3, 03.2007, p. 379-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alcohol consumption and risk of leukemia
T2 - A multicenter case-control study
AU - Gorini, Giuseppe
AU - Stagnaro, Emanuele
AU - Fontana, Vincenzo
AU - Miligi, Lucia
AU - Ramazzotti, Valerio
AU - Nanni, Oriana
AU - Rodella, Stefania
AU - Tumino, Rosario
AU - Crosignani, Paolo
AU - Vindigni, Carla
AU - Fontana, Arabella
AU - Vineis, Paolo
AU - Costantini, Adele Seniori
PY - 2007/3
Y1 - 2007/3
N2 - A population-based case-control study of 649 leukemia cases and 1771 controls carried out in 11 Italian areas, offered the opportunity to evaluate the relationship between alcohol consumption and leukemia risk. For all leukemias, acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL), we found a non-significantly inverse association for moderate levels of total alcohol and wine intake, but increased risks at high levels, with, in most cases, significant trend effects (odd ratios (OR) for all leukemias in the lowest quartile of total alcohol consumption [0.1-9.0 g/day of ethanol] versus never-drinker = 0.73; 95% confidence intervals (95% CI) = 0.51-1.03; OR in the highest quartile [> 31.7 g/day] = 1.15; 95% CI = 0.82-1.63; p of the linear trend test = 0.007). For chronic myeloid leukemia (CML), we found a non-significantly positive association for all levels of total alcohol and wine intake, and a significant positive linear trend effect (p = 0.03) for wine intake (OR for 0.1-9.0 g/day of ethanol intake from wine = 1.34; 95% CI = 0.61-2.94; OR in the highest quartile of wine intake [> 27.7 g/day] = 2.13; 95% CI = 1.01-4.50). No consistent dose-response was detected analysing duration of alcohol consumption for any leukemia subtypes. In conclusion, even though our study did not show a clear association between alcohol intake and leukemia risk, some of the patterns of the risk estimates (a possible J-shaped dose-response curve between alcohol intake and ALL, AML, and CLL risks, and the positive association between alcohol and CML), may be suggestive.
AB - A population-based case-control study of 649 leukemia cases and 1771 controls carried out in 11 Italian areas, offered the opportunity to evaluate the relationship between alcohol consumption and leukemia risk. For all leukemias, acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL), we found a non-significantly inverse association for moderate levels of total alcohol and wine intake, but increased risks at high levels, with, in most cases, significant trend effects (odd ratios (OR) for all leukemias in the lowest quartile of total alcohol consumption [0.1-9.0 g/day of ethanol] versus never-drinker = 0.73; 95% confidence intervals (95% CI) = 0.51-1.03; OR in the highest quartile [> 31.7 g/day] = 1.15; 95% CI = 0.82-1.63; p of the linear trend test = 0.007). For chronic myeloid leukemia (CML), we found a non-significantly positive association for all levels of total alcohol and wine intake, and a significant positive linear trend effect (p = 0.03) for wine intake (OR for 0.1-9.0 g/day of ethanol intake from wine = 1.34; 95% CI = 0.61-2.94; OR in the highest quartile of wine intake [> 27.7 g/day] = 2.13; 95% CI = 1.01-4.50). No consistent dose-response was detected analysing duration of alcohol consumption for any leukemia subtypes. In conclusion, even though our study did not show a clear association between alcohol intake and leukemia risk, some of the patterns of the risk estimates (a possible J-shaped dose-response curve between alcohol intake and ALL, AML, and CLL risks, and the positive association between alcohol and CML), may be suggestive.
KW - Adult leukemia
KW - Alcohol
KW - Case-control study
UR - http://www.scopus.com/inward/record.url?scp=33846048929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846048929&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2006.07.002
DO - 10.1016/j.leukres.2006.07.002
M3 - Article
C2 - 16919329
AN - SCOPUS:33846048929
VL - 31
SP - 379
EP - 386
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 3
ER -