Alcohol consumption and risk of leukemia: A multicenter case-control study

Giuseppe Gorini, Emanuele Stagnaro, Vincenzo Fontana, Lucia Miligi, Valerio Ramazzotti, Oriana Nanni, Stefania Rodella, Rosario Tumino, Paolo Crosignani, Carla Vindigni, Arabella Fontana, Paolo Vineis, Adele Seniori Costantini

Research output: Contribution to journalArticle

Abstract

A population-based case-control study of 649 leukemia cases and 1771 controls carried out in 11 Italian areas, offered the opportunity to evaluate the relationship between alcohol consumption and leukemia risk. For all leukemias, acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL), we found a non-significantly inverse association for moderate levels of total alcohol and wine intake, but increased risks at high levels, with, in most cases, significant trend effects (odd ratios (OR) for all leukemias in the lowest quartile of total alcohol consumption [0.1-9.0 g/day of ethanol] versus never-drinker = 0.73; 95% confidence intervals (95% CI) = 0.51-1.03; OR in the highest quartile [> 31.7 g/day] = 1.15; 95% CI = 0.82-1.63; p of the linear trend test = 0.007). For chronic myeloid leukemia (CML), we found a non-significantly positive association for all levels of total alcohol and wine intake, and a significant positive linear trend effect (p = 0.03) for wine intake (OR for 0.1-9.0 g/day of ethanol intake from wine = 1.34; 95% CI = 0.61-2.94; OR in the highest quartile of wine intake [> 27.7 g/day] = 2.13; 95% CI = 1.01-4.50). No consistent dose-response was detected analysing duration of alcohol consumption for any leukemia subtypes. In conclusion, even though our study did not show a clear association between alcohol intake and leukemia risk, some of the patterns of the risk estimates (a possible J-shaped dose-response curve between alcohol intake and ALL, AML, and CLL risks, and the positive association between alcohol and CML), may be suggestive.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalLeukemia Research
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Alcohol Drinking
Wine
Case-Control Studies
Leukemia
Alcohols
Odds Ratio
Confidence Intervals
B-Cell Chronic Lymphocytic Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Ethanol
Population

Keywords

  • Adult leukemia
  • Alcohol
  • Case-control study

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Alcohol consumption and risk of leukemia : A multicenter case-control study. / Gorini, Giuseppe; Stagnaro, Emanuele; Fontana, Vincenzo; Miligi, Lucia; Ramazzotti, Valerio; Nanni, Oriana; Rodella, Stefania; Tumino, Rosario; Crosignani, Paolo; Vindigni, Carla; Fontana, Arabella; Vineis, Paolo; Costantini, Adele Seniori.

In: Leukemia Research, Vol. 31, No. 3, 03.2007, p. 379-386.

Research output: Contribution to journalArticle

Gorini, G, Stagnaro, E, Fontana, V, Miligi, L, Ramazzotti, V, Nanni, O, Rodella, S, Tumino, R, Crosignani, P, Vindigni, C, Fontana, A, Vineis, P & Costantini, AS 2007, 'Alcohol consumption and risk of leukemia: A multicenter case-control study', Leukemia Research, vol. 31, no. 3, pp. 379-386. https://doi.org/10.1016/j.leukres.2006.07.002
Gorini, Giuseppe ; Stagnaro, Emanuele ; Fontana, Vincenzo ; Miligi, Lucia ; Ramazzotti, Valerio ; Nanni, Oriana ; Rodella, Stefania ; Tumino, Rosario ; Crosignani, Paolo ; Vindigni, Carla ; Fontana, Arabella ; Vineis, Paolo ; Costantini, Adele Seniori. / Alcohol consumption and risk of leukemia : A multicenter case-control study. In: Leukemia Research. 2007 ; Vol. 31, No. 3. pp. 379-386.
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