Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis

Lindsay M. Morton, Tongzhang Zheng, Theodore R. Holford, Elizabeth A. Holly, Brian C H Chiu, Adele Seniori Costantini, Emanuele Stagnaro, Eleanor V. Willett, Luigino Dal Maso, Diego Serraino, Ellen T. Chang, Wendy Cozen, Scott Davis, Richard K. Severson, Leslie Bernstein, Susan T. Mayne, Fred R. Dee, James R. Cerhan, Patricia Hartge

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Abstract

Background: Previous epidemiological studies of the relation between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) have been inconsistent, probably because of small sample sizes of individual studies that result from stratification by NHL subtype and type of alcoholic beverage. We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype. Methods: We obtained original data from nine case-control studies from the USA, UK, Sweden, and Italy in the International Lymphoma Epidemiology Consortium (InterLymph), yielding a pooled study population of 15175 individuals (6492 cases and 8683 controls). We derived odds ratios (OR) and 95% CI from unconditional logistic regression models, controlling for study centre and other confounding factors. Heterogeneity between studies was assessed by comparison of results from joint fixed-effects logistic regression and two-stage random-effects logistic regression, and by calculation of Wald χ2 statistics. Findings: People who drank alcohol had a lower risk of NHL than did non-drinkers (OR 0·83 [95% CI 0·76-0·89]). Compared with non-drinkers, risk estimates were lower for current drinkers than for former drinkers (0·73 [0·64-0·84] vs 0·95 [0·80-1·14]), but risk did not decrease with increasing alcohol consumption. The protective effect of alcohol did not vary by beverage type, but did change with NHL subtype. The lowest risk estimates were recorded for Burkitt's lymphoma (0·51 [0·33-0·77]). Interpretation: People who drink alcoholic beverages might have a lower risk of NHL than those who do not, and this risk might vary by NHL subtype. Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalThe Lancet Oncology
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2005

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Alcohol Drinking
Non-Hodgkin's Lymphoma
Alcoholic Beverages
Logistic Models
Alcohols
Sample Size
Odds Ratio
Burkitt Lymphoma
Beverages
Sweden
Italy
Case-Control Studies
Life Style
Epidemiologic Studies
Lymphoma
Epidemiology
Joints
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Morton, L. M., Zheng, T., Holford, T. R., Holly, E. A., Chiu, B. C. H., Costantini, A. S., ... Hartge, P. (2005). Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis. The Lancet Oncology, 6(7), 469-476. https://doi.org/10.1016/S1470-2045(05)70214-X

Alcohol consumption and risk of non-Hodgkin lymphoma : A pooled analysis. / Morton, Lindsay M.; Zheng, Tongzhang; Holford, Theodore R.; Holly, Elizabeth A.; Chiu, Brian C H; Costantini, Adele Seniori; Stagnaro, Emanuele; Willett, Eleanor V.; Dal Maso, Luigino; Serraino, Diego; Chang, Ellen T.; Cozen, Wendy; Davis, Scott; Severson, Richard K.; Bernstein, Leslie; Mayne, Susan T.; Dee, Fred R.; Cerhan, James R.; Hartge, Patricia.

In: The Lancet Oncology, Vol. 6, No. 7, 07.2005, p. 469-476.

Research output: Contribution to journalArticle

Morton, LM, Zheng, T, Holford, TR, Holly, EA, Chiu, BCH, Costantini, AS, Stagnaro, E, Willett, EV, Dal Maso, L, Serraino, D, Chang, ET, Cozen, W, Davis, S, Severson, RK, Bernstein, L, Mayne, ST, Dee, FR, Cerhan, JR & Hartge, P 2005, 'Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis', The Lancet Oncology, vol. 6, no. 7, pp. 469-476. https://doi.org/10.1016/S1470-2045(05)70214-X
Morton LM, Zheng T, Holford TR, Holly EA, Chiu BCH, Costantini AS et al. Alcohol consumption and risk of non-Hodgkin lymphoma: A pooled analysis. The Lancet Oncology. 2005 Jul;6(7):469-476. https://doi.org/10.1016/S1470-2045(05)70214-X
Morton, Lindsay M. ; Zheng, Tongzhang ; Holford, Theodore R. ; Holly, Elizabeth A. ; Chiu, Brian C H ; Costantini, Adele Seniori ; Stagnaro, Emanuele ; Willett, Eleanor V. ; Dal Maso, Luigino ; Serraino, Diego ; Chang, Ellen T. ; Cozen, Wendy ; Davis, Scott ; Severson, Richard K. ; Bernstein, Leslie ; Mayne, Susan T. ; Dee, Fred R. ; Cerhan, James R. ; Hartge, Patricia. / Alcohol consumption and risk of non-Hodgkin lymphoma : A pooled analysis. In: The Lancet Oncology. 2005 ; Vol. 6, No. 7. pp. 469-476.
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