Alcohol consumption and site-specific cancer risk

A comprehensive dose-response meta-analysis

V. Bagnardi, M. Rota, E. Botteri, I. Tramacere, F. Islami, V. Fedirko, L. Scotti, M. Jenab, F. Turati, E. Pasquali, C. Pelucchi, C. Galeone, R. Bellocco, E. Negri, G. Corrao, P. Boffetta, C. La Vecchia

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

Original languageEnglish
Pages (from-to)580-593
Number of pages14
JournalBritish Journal of Cancer
Volume112
Issue number3
DOIs
Publication statusPublished - Feb 3 2015

Fingerprint

Alcohol Drinking
Meta-Analysis
Mouth Neoplasms
Neoplasms
Pharyngeal Neoplasms
Alcohols
Larynx
Esophagus
Mouth
Liver
Melanoma
Prostatic Neoplasms
Breast
Pharynx
Gallbladder
Hodgkin Disease
Pancreatic Neoplasms
Non-Hodgkin's Lymphoma
Stomach Neoplasms
Pancreas

Keywords

  • alcohol
  • dose-response
  • epidemiology
  • meta-analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Alcohol consumption and site-specific cancer risk : A comprehensive dose-response meta-analysis. / Bagnardi, V.; Rota, M.; Botteri, E.; Tramacere, I.; Islami, F.; Fedirko, V.; Scotti, L.; Jenab, M.; Turati, F.; Pasquali, E.; Pelucchi, C.; Galeone, C.; Bellocco, R.; Negri, E.; Corrao, G.; Boffetta, P.; La Vecchia, C.

In: British Journal of Cancer, Vol. 112, No. 3, 03.02.2015, p. 580-593.

Research output: Contribution to journalArticle

Bagnardi, V, Rota, M, Botteri, E, Tramacere, I, Islami, F, Fedirko, V, Scotti, L, Jenab, M, Turati, F, Pasquali, E, Pelucchi, C, Galeone, C, Bellocco, R, Negri, E, Corrao, G, Boffetta, P & La Vecchia, C 2015, 'Alcohol consumption and site-specific cancer risk: A comprehensive dose-response meta-analysis', British Journal of Cancer, vol. 112, no. 3, pp. 580-593. https://doi.org/10.1038/bjc.2014.579
Bagnardi, V. ; Rota, M. ; Botteri, E. ; Tramacere, I. ; Islami, F. ; Fedirko, V. ; Scotti, L. ; Jenab, M. ; Turati, F. ; Pasquali, E. ; Pelucchi, C. ; Galeone, C. ; Bellocco, R. ; Negri, E. ; Corrao, G. ; Boffetta, P. ; La Vecchia, C. / Alcohol consumption and site-specific cancer risk : A comprehensive dose-response meta-analysis. In: British Journal of Cancer. 2015 ; Vol. 112, No. 3. pp. 580-593.
@article{963bdfbe1fa843d78d5a99ad5e30bb79,
title = "Alcohol consumption and site-specific cancer risk: A comprehensive dose-response meta-analysis",
abstract = "Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.",
keywords = "alcohol, dose-response, epidemiology, meta-analysis",
author = "V. Bagnardi and M. Rota and E. Botteri and I. Tramacere and F. Islami and V. Fedirko and L. Scotti and M. Jenab and F. Turati and E. Pasquali and C. Pelucchi and C. Galeone and R. Bellocco and E. Negri and G. Corrao and P. Boffetta and {La Vecchia}, C.",
year = "2015",
month = "2",
day = "3",
doi = "10.1038/bjc.2014.579",
language = "English",
volume = "112",
pages = "580--593",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Alcohol consumption and site-specific cancer risk

T2 - A comprehensive dose-response meta-analysis

AU - Bagnardi, V.

AU - Rota, M.

AU - Botteri, E.

AU - Tramacere, I.

AU - Islami, F.

AU - Fedirko, V.

AU - Scotti, L.

AU - Jenab, M.

AU - Turati, F.

AU - Pasquali, E.

AU - Pelucchi, C.

AU - Galeone, C.

AU - Bellocco, R.

AU - Negri, E.

AU - Corrao, G.

AU - Boffetta, P.

AU - La Vecchia, C.

PY - 2015/2/3

Y1 - 2015/2/3

N2 - Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

AB - Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

KW - alcohol

KW - dose-response

KW - epidemiology

KW - meta-analysis

UR - http://www.scopus.com/inward/record.url?scp=84922239662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922239662&partnerID=8YFLogxK

U2 - 10.1038/bjc.2014.579

DO - 10.1038/bjc.2014.579

M3 - Article

VL - 112

SP - 580

EP - 593

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 3

ER -